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Results Found: 22
  • Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas)

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of 487 lung squamous cell carcinomas from 487 patients. The data was gathered as part of the PanCancer Atlas initiative, which aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset. The clinical data includes mutation count, information...

    Subject
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Squamous Cell
    DNA Mutational Analysis
    Access Rights
    Free to All
  • MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017): Targeted sequencing of 10,000 clinical cases using the MSK-IMPACT assay

    Description

    This dataset contains summary data visualizations and clinical data from the targeted sequencing of 10,000 clinical cases using the MSK-IMPACT assay. The clinical data includes mutation count, information about mutated genes, tumor mutational burden calculations, tissue site from which the sample was derived, tumor purity among other relevant data points. The data set also includes copy-number segment...

    Subject
    Adenocarcinoma
    Adenocarcinoma of Lung
    Adenocarcinoma, Mucinous
    Breast Neoplasms
    Carcinoma, Ductal, Breast
    Carcinoma, Hepatocellular
    Carcinoma, Lobular
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Renal Cell
    Carcinoma, Squamous Cell
    Carcinosarcoma
    Cholangiocarcinoma
    Colonic Neoplasms
    Colorectal Neoplasms
    Cystadenocarcinoma, Serous
    DNA Mutational Analysis
    Gallbladder Neoplasms
    Glioblastoma
    Liposarcoma
    Lung Neoplasms
    Lymphoma, Follicular
    Melanoma
    Mesothelioma
    Neoplasms, Squamous Cell
    Neurofibroma
    Oligodendroglioma
    Osteosarcoma
    Ovarian Neoplasms
    Pancreatic Neoplasms
    Prostatic Neoplasms
    Rectal Neoplasms
    Sarcoma
    Sarcoma, Synovial
    Squamous Cell Carcinoma of Head and Neck
    Stomach Neoplasms
    Thyroid Cancer, Papillary
    Urinary Bladder Neoplasms
    Uterine Neoplasms
    Uveal Neoplasms
    Access Rights
    Free to All
  • SUMMIT - Neratinib Basket Study (Multi-Institute, Nature 2018): MSK-IMPACT sequencing of 86 patients with HER2- and HER3-mutant cancers

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of HER2- and HER3-mutant tumors. The data was generated utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, Amplification Status, Best objective response rate, Bubble...

    Subject
    Breast Neoplasms
    Carcinoma, Hepatocellular
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Renal Cell
    Colorectal Neoplasms
    DNA Mutational Analysis
    Endometrial Neoplasms
    Esophageal Neoplasms
    Genes, erbB
    Genes, erbB-2
    Melanoma
    Ovarian Neoplasms
    Pancreatic Neoplasms
    Salivary Gland Neoplasms
    Sarcoma
    Skin Neoplasms
    Urinary Bladder Neoplasms
    Uterine Cervical Neoplasms
    Access Rights
    Free to All
  • Thoracic PDX (MSK, Provisional): Targeted sequencing of thoracic PDX lines to characterize genetic alterations in 139 tumor/normal pairs via MSK-IMPACT.

    Description

    This dataset contains summary data visualizations and clinical data from a broad 183 samples of thoracic tumors from 77 patients. The data was generated by the Charles Rudin Lab, utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, patient demographics,...

    Subject
    Adenocarcinoma of Lung
    Carcinoma, Non-Small-Cell Lung
    DNA Mutational Analysis
    Lung Neoplasms
    Mesothelioma
    Access Rights
    Free to All
  • Lung Squamous Cell Carcinoma (TCGA, Firehose Legacy)

    Description

    TCGA Lung Squamous Cell Carcinoma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 511 carcinomas from 511 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information...

    Subject
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Squamous Cell
    DNA Mutational Analysis
    Lung Neoplasms
    Access Rights
    Free to All
  • Molecular portraits of tumor mutational and micro-environmental sculpting by immune checkpoint blockade therapy

    Authors
    Riaz, Nadeem
    Havel, Jonathan J.
    Makarov, Vladimir
    Desrichard, Alexis
    1 more author(s)...
    Description

    Summary from the GEO: "Immune checkpoint blockade (ICB) has demonstrated significant promise for the treatment of advanced malignancies. Anti-CTLA4 and ant-PD1 therapy can activate the immune system and result in durable control in diseases such as melanoma and non-small cell lung cancer. 109 RNASeq samples (58 On-treatment and 51 Pre-treatment) from 65 patients." Abstract from the publication that...

    Subject
    Carcinoma, Non-Small-Cell Lung
    Immunotherapy
    Melanoma
    Access Rights
    Free to All
  • Mixed cfDNA (MSK, Nature Medicine 2019): Targeted sequencing of 248 samples from 124 patients' cfDNA/WBC and tumor/normal pairs.

    Description

    This dataset contains the summary data visualizations and clinical data of targeted sequencing of 248 samples from 124 patients' cfDNA/WBC[White Blood Cell] and tumor/normal pairs. Clinical data includes: Cancer Type, Mutation Count, Age, Tumor Type, cfDNA TMB, Collapsed fragment mean coverage, Collapsed mean coverage, ctDNA Fraction, MSI Score, Oncotree Code, cfDNA/Tumor Sample Class, Tumor Tissue...

    Subject
    Breast Neoplasms
    Carcinoma, Non-Small-Cell Lung
    Cell-Free Nucleic Acids
    Prostatic Neoplasms
    Access Rights
    Free to All
  • Non-Small Cell Cancer (MSKCC, Cancer Discov 2017): Targeted sequencing of 860 patients with metastatic lung adenocarcinoma

    Description

    This dataset contains the summary data visualizations and clinical data from targeted sequencing of 915 samples from 860 patients with metastatic lung adenocarcinoma. Clinical data includes: Number of Samples Per Patient, Mutation Count, Fraction Genome Altered, Diagnosis Age, Sex, Primary/Metastasis Sample Type, Chemotherapy, Clinical Trial, Driver Mutations, Durable Clinical Benefit, Gene Panel,...

    Subject
    Adenocarcinoma
    Adenocarcinoma of Lung
    Carcinoma, Non-Small-Cell Lung
    Lung Neoplasms
    Access Rights
    Free to All
  • Non-Small Cell Lung Cancer (MSK, Cancer Cell 2018): Whole-exome sequencing of 75 tumor/normal NSCLC pairs treated with PD-1 plus CTLA-4 blockade

    Description

    This dataset contains the summary data visualizations and clinical data from whole-exome sequencing of 75 tumor/normal NSCLC pairs treated with PD-1 plus CTLA-4 blockade from 75 patients. Clinical data includes: Mutation Count, Sex, Histology, Age (yrs), Best Overall Response, Durable Clinical Benefit, ECOG performance status, HLA_A1 allele, HLA_A2 alleles, HLA_B1 alleles, HLA_B2 alleles, HLA_C1 alleles,...

    Subject
    Carcinoma, Non-Small-Cell Lung
    Immune Checkpoint Inhibitors
    Lung Neoplasms
    Access Rights
    Free to All
  • Non-Small Cell Lung Cancer (MSKCC, J Clin Oncol 2018): IMPACT sequencing of 240 NSCLC tumor/normal pairs treated at MSKCC with anti-PD-(L)1 based therapy.

    Description

    This dataset contains the summary data visualizations and clinical data from IMPACT sequencing of 240 NSCLC tumor/normal pairs treated at MSKCC with anti-PD-(L)1 based therapy from 240 patients. Clinical data includes: Cancer Type, Mutation Count, Fraction Genome Altered, Sex, Durable Clinical Benefit, FGA, Gene Panel, IRB, Lines of treatment, Mutation Rate, Oncotree Code, PD-L1 Score (%), Smoker,...

    Subject
    Adenocarcinoma of Lung
    Carcinoma, Large Cell
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Squamous Cell
    Lung Neoplasms
    Access Rights
    Free to All