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  • Flow Cytometry Datasets Associated with Single-cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment research

    Authors
    Cornish, Andrew Erickson
    Description

    The purpose of the dataset from the Flow Repository: "To determine the degree to which populations of intratumoral T cells, especially but not limited to T regs, initially found in single cell RNA sequencing data may be reproduced in mass cytometry data." From the description on Flow Repository: The data included for each of the 3 patients (BC12, BC13, and BC14, respectively) is presented in nine...

    Subject
    Breast Neoplasms
    Gene Expression Profiling
    Gene Expression Regulation, Neoplastic
    Immunotherapy
    Leukocytes, Mononuclear
    Lymphocytes, Tumor-Infiltrating
    Tumor Microenvironment/immunology
    Timeframe
    2018
    Access Rights
    Free to All
  • Cellular states, clonal dynamics, and evolution in Pearson syndrome revealed via single-cell multi-omics [PBMC_scRNA]

    Authors
    Lareau, Caleb A.
    Ludwig, Leif S.
    Description

    Summary from GEO: "Large deletions in mitochondrial DNA (mtDNA) have been linked to a variety of clinical pathologies, including somatic emergence in congenital disorders such as Pearson Syndrome (MIM:557000), a mitochondrial disease characterized by sideroblastic anemia and exocrine pancreas dysfunction. Here, we develop a multi-omics approach to quantify mtDNA deletion heteroplasmy and cell state...

    Subject
    Anemia, Sideroblastic
    Gene Expression Profiling
    Genomics
    Heteroplasmy/genetics
    Leukocytes, Mononuclear
    Myelodysplastic Syndromes
    Single-Cell Analysis
    Access Rights
    Free to All
  • Cellular states, clonal dynamics, and evolution in Pearson syndrome revealed via single-cell multi-omics [PBMC_scATAC]

    Authors
    Lareau, Caleb A.
    Ludwig, Leif S.
    Description

    Summary from GEO: "Large deletions in mitochondrial DNA (mtDNA) have been linked to a variety of clinical pathologies, including somatic emergence in congenital disorders such as Pearson Syndrome (MIM:557000), a mitochondrial disease characterized by sideroblastic anemia and exocrine pancreas dysfunction. Here, we develop a multi-omics approach to quantify mtDNA deletion heteroplasmy and cell state...

    Subject
    Anemia, Sideroblastic
    Binding sites
    Genomics
    Heteroplasmy/genetics
    Leukocytes, Mononuclear
    Myelodysplastic Syndromes
    Single-Cell Analysis
    Access Rights
    Free to All
  • High throughput joint profiling of chromatin accessibility and protein levels in single cells [PBMC_Stim_Multiome]

    Authors
    Mimitou, Eleni P.
    Lareau, Caleb A.
    Chen, Kelvin Y.
    Ludwig, Leif S.
    1 more author(s)...
    Description

    Summary from GEO: "Recent technological advances have enabled massively parallel single-cell Assay for Transposase Accessible Chromatin by sequencing (scATAC-seq) to simultaneously profile the epigenomic landscape in thousands of individual cells. scATAC-seq methods sample genomic DNA accessible to transposases, but have not previously been combined with measurement of protein levels. Here, we present...

    Subject
    CD28 Antigens
    CD3 Complex
    Cell Differentiation
    Chromatin Immunoprecipitation Sequencing
    Hematopoiesis
    Leukocytes, Mononuclear
    Access Rights
    Free to All
  • High throughput joint profiling of chromatin accessibility and protein levels in single cells [PBMCs]

    Authors
    Mimitou, Eleni P.
    Lareau, Caleb A.
    Chen, Kelvin Y.
    Ludwig, Leif S.
    1 more author(s)...
    Description

    Summary from GEO: "Recent technological advances have enabled massively parallel single-cell Assay for Transposase Accessible Chromatin by sequencing (scATAC-seq) to simultaneously profile the epigenomic landscape in thousands of individual cells. scATAC-seq methods sample genomic DNA accessible to transposases, but have not previously been combined with measurement of protein levels. Here, we present...

    Subject
    Cell Differentiation
    Gene Expression Profiling
    Hematopoiesis
    Leukocytes, Mononuclear
    Access Rights
    Free to All