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Results Found: 3
  • Genomic characterisation of MGUS

    Description

    Dataset Description from EGA: "The hematological malignancy multiple myeloma (MM), also called Kahler's disease or plasma cell (PC) myeloma, is characterized by a clonal expansion of PCs originating in the bone marrow (BM). The expansion of these cells leads to an overproduction of antibodies and results in typical symptoms such as anemia, renal failure and bone lesions. All cases of MM are preceded...

    Subject
    Monoclonal Gammopathy of Undetermined Significance
    Multiple Myeloma
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    Application Required
  • 33 patients with Monoclonal Gammopathy of Undetermined Significance (MGUS)

    Description

    Dataset Description from EGA: " Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant precursor of multiple myeloma (MM) with a 1% risk of progression per year. Although targeted analyses have shown the presence of specific genetic abnormalities such as IGH translocations, RB1 deletion, 1q gain, hyperdiploidy or RAS genes mutations, little is known about molecular mechanism of...

    Subject
    Monoclonal Gammopathy of Undetermined Significance
    Multiple Myeloma
    Oncogene Proteins, Fusion
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    Application Required
  • Multiple Myeloma Diagnosis to Relapse study samples (2017-04-27)

    Description

    Dataset Description from EGA: " The study will investigate serial samples from the same patient taken at the time of MGUS or SMM diagnosis, and later at the time of evolution towards MM. Samples will be sequenced by whole genome along with a matched normal to obtain the highest possible amount of information toinvestigate genomic changes at disease evolution. This dataset contains all the data available...

    Subject
    Monoclonal Gammopathy of Undetermined Significance
    Smoldering Multiple Myeloma
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    Application Required