Search Tips
of 2 Next >
Results Found: 12
  • Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of 585 ovarian serous cystadenocarcinomas from 585 patients. The data was gathered as part of the PanCancer Atlas initiative, which aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset. The clinical data includes mutation count, information...

    Subject
    Cystadenocarcinoma, Serous
    DNA Mutational Analysis
    Ovarian Neoplasms
    Access Rights
    Free to All
  • MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017): Targeted sequencing of 10,000 clinical cases using the MSK-IMPACT assay

    Description

    This dataset contains summary data visualizations and clinical data from the targeted sequencing of 10,000 clinical cases using the MSK-IMPACT assay. The clinical data includes mutation count, information about mutated genes, tumor mutational burden calculations, tissue site from which the sample was derived, tumor purity among other relevant data points. The data set also includes copy-number segment...

    Subject
    Adenocarcinoma
    Adenocarcinoma of Lung
    Adenocarcinoma, Mucinous
    Breast Neoplasms
    Carcinoma, Ductal, Breast
    Carcinoma, Hepatocellular
    Carcinoma, Lobular
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Renal Cell
    Carcinoma, Squamous Cell
    Carcinosarcoma
    Cholangiocarcinoma
    Colonic Neoplasms
    Colorectal Neoplasms
    Cystadenocarcinoma, Serous
    DNA Mutational Analysis
    Gallbladder Neoplasms
    Glioblastoma
    Liposarcoma
    Lung Neoplasms
    Lymphoma, Follicular
    Melanoma
    Mesothelioma
    Neoplasms, Squamous Cell
    Neurofibroma
    Oligodendroglioma
    Osteosarcoma
    Ovarian Neoplasms
    Pancreatic Neoplasms
    Prostatic Neoplasms
    Rectal Neoplasms
    Sarcoma
    Sarcoma, Synovial
    Squamous Cell Carcinoma of Head and Neck
    Stomach Neoplasms
    Thyroid Cancer, Papillary
    Urinary Bladder Neoplasms
    Uterine Neoplasms
    Uveal Neoplasms
    Access Rights
    Free to All
  • SUMMIT - Neratinib Basket Study (Multi-Institute, Nature 2018): MSK-IMPACT sequencing of 86 patients with HER2- and HER3-mutant cancers

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of HER2- and HER3-mutant tumors. The data was generated utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, Amplification Status, Best objective response rate, Bubble...

    Subject
    Breast Neoplasms
    Carcinoma, Hepatocellular
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Renal Cell
    Colorectal Neoplasms
    DNA Mutational Analysis
    Endometrial Neoplasms
    Esophageal Neoplasms
    Genes, erbB
    Genes, erbB-2
    Melanoma
    Ovarian Neoplasms
    Pancreatic Neoplasms
    Salivary Gland Neoplasms
    Sarcoma
    Skin Neoplasms
    Urinary Bladder Neoplasms
    Uterine Cervical Neoplasms
    Access Rights
    Free to All
  • NCI-60 Cell Lines (NCI, Cancer Res 2012): Whole-exome sequencing of 67 samples by NCI-60 cell line project

    Description

    This dataset contains summary data visualizations and clinical data from 67 samples from 67 patients as part an NCI-60 cell line project to compile NCI-60 cell line high-throughput and high-content data into CellMiner, a genomic and pharmacologic database created by the National Cancer Center Institute. The clinical data includes deidentified patient and sample IDs, mutation counts, detailed cancer...

    Subject
    Adenocarcinoma
    Brain Neoplasms
    Breast Neoplasms
    Carcinoma, Renal Cell
    Colorectal Neoplasms
    DNA Mutational Analysis
    Leukemia, Myeloid
    Lung Neoplasms
    Melanoma
    Ovarian Neoplasms
    Prostatic Neoplasms
    Access Rights
    Free to All
  • Ovarian Serous Cystadenocarcinoma (TCGA Firehose Legacy)

    Description

    TCGA Ovarian Serous Cystadenocarcinoma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 617 carcinomas from 600 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count,...

    Subject
    Cystadenocarcinoma, Serous
    DNA Mutational Analysis
    Ovarian Neoplasms
    Access Rights
    Free to All
  • Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) - OncoArray Genotypes

    Authors
    Amos, Christopher I.
    Couch, Fergus J.
    Description

    Study Description from dbGaP: "The data come from 40 studies participating in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). CIMBA recruits individuals with pathogenic mutations in BRCA1 or BRCA2. The majority of carriers were recruited through cancer genetics clinics offering genetic testing, and were enrolled into national or regional studies. The remainder were identified by population-based...

    Subject
    BRCA1 Protein
    BRCA2 Protein
    Breast Neoplasms
    Genetic Loci
    Genome-Wide Association Study
    Ovarian Neoplasms
    Access Rights
    Application Required
  • RNA-seq for UBR5-regulated genes in tumor associated macrophages

    Authors
    Song, Mei
    Zhang, Tuo
    Description

    Summary from the GEO: "RNA-seq analysis of peritoneal macrophages derived from non-tumor bearing, WT ID8 tumor-bearing, and Ubr5 KO ID8 tumor bearing C57BL/6 mice." From the publication abstract: "Immunosuppressive tumor microenvironment (TME) and ascites-derived spheroids in ovarian cancer (OC) facilitate tumor growth and progression, and also pose major obstacles for cancer therapy. The molecular...

    Subject
    Macrophages, Peritoneal
    Ovarian Neoplasms
    Ubiquitin-Protein Ligases
    Access Rights
    Free to All
  • Notch3 signaling promotes tumor cell adhesion and progression in a murine epithelial ovarian cancer model

    Authors
    Price, Jessica C.
    Azizi, Elham
    Parvani, Jenny G.
    Shukla, Priyanka
    5 more author(s)...
    Description

    Summary from GEO: "High grade serous ovarian cancer (HGSC) is the most common and deadly type of ovarian cancer, largely due to difficulties in early diagnosis and rapid metastasis throughout the peritoneal cavity. Previous studies have shown that expression of Notch3 correlates with worse prognosis and increased tumorigenic cell behaviors in HGSC. We investigated the mechanistic role of Notch3 in...

    Subject
    Carcinogenesis
    Carcinoma, Ovarian Epithelial
    Epithelial Cells
    Ovarian Neoplasms
    Receptor, Notch3
    RNA-Seq
    Access Rights
    Free to All
  • Senescence induction dictates response and resistance to chemo- and immunotherapy in preclinical models of ovarian cancer

    Authors
    Paffenholz, Stella V.
    Salvagno, Camilla
    Ho, Yu-jui
    Limjoco, Matthew
    10 more author(s)...
    Description

    Summary from GEO: "High-grade serous ovarian carcinoma (HGSOC) is associated with a dismal prognosis. While most patients initially respond to platinum-based chemotherapy, they almost always acquire resistance, and only a small subset of HGSOC patients benefit from immune checkpoint blockade (ICB). To elucidate the disease mechanisms and factors underlying sensitivity and resistance to conventional...

    Subject
    Carcinoma, Ovarian Epithelial
    Cellular Senescence
    Homologous Recombination
    Immune Checkpoint Inhibitors
    Ovarian Neoplasms
    Access Rights
    Free to All
  • Small Cell Carcinoma of the Ovary (MSK, Nat Genet 2014): Targeted sequencing of 12 SCCO paired tumor and normal samples.

    Authors
    Jelinic, Petar
    Mueller, Jennifer J.
    Olvera, Narciso
    Dao, Fanny
    8 more author(s)...
    Description

    Targeted sequencing of small cell carcinoma of the ovary, a rare, highly aggressive form of ovarian cancer primarily diagnosed in young women. This dataset contains visual summaries and clinical data from 12 patients. Data includes molecular profiles, information on mutations, and patient demographics.

    Subject
    Carcinoma, Small Cell
    Ovarian Neoplasms
    Access Rights
    Free to All