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TMB and Immunotherapy (MSKCC, Nat Genet 2019): Genomic and survival data from 1661 tumor-normal pairs from 1661 patients with various cancer types sequenced with the MSK-IMPACT assay.
- Description
This dataset contains summary data visualizations and clinical data from a broad sampling of 1,661 samples of across multiple cancer types showing tumor mutational load and survival following immunotherapy from 1,661 patients. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK),...
- Subject
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DNA Mutational AnalysisImmunotherapyMutationTumor Burden
- Access Rights
- Free to All
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Skin Cutaneous Melanoma (TCGA, Firehose Legacy)
- Description
TCGA Skin Cutaneous Melanoma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 480 carcinomas from 471 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information...
- Subject
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DNA Mutational AnalysisMelanomaSkin Neoplasms
- Access Rights
- Free to All
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Desmoplastic Melanoma (Broad Institute, Nat Genet 2015): Exome/Whole Genome sequencing of 20 desmoplastic melanoma tumor/normal pairs
- Description
This dataset contains the summary data visualizations and clinical data of Exome/Whole Genome sequencing of 20 desmoplastic melanoma tumor/normal pairs. Clinical data includes: Mutation Count, Diagnosis Age, Anatomic Region, Detailed Sample Histology Category, Platform, Secondary Platform, Total Mutations, and Tumor Other Histologic Subtype. The plaintext components of the dataset can be downloaded...
- Subject
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MelanomaSkin Neoplasms
- Access Rights
- Free to All
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Desmoplastic Melanoma
- Authors
- Shain, Alan H.Bastian, Boris C.
- Description
Summary from the GEO: " High resolution aCGH was performed on 10 primary Desmoplastic Melanomas (DMs). DMs are a rare subtype of melanoma known for their pronounced desmoplastic stroma and spindled melanocytes. 10 samples were hybridized to Agilent 1 Million feature two color arrays as compared to a panel of normal male DNA. 6 samples were hybridized to Agilent 244K feature two color arrays as compared...
- Subject
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MelanomaSkin Neoplasms
- Access Rights
- Free to All
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High response rate to anti PD-1 therapy in desmoplastic melanoma
- Authors
- Ribas, Antoni
- Description
Study Description from dbGaP: Desmoplastic melanoma (DM) is a rare subtype of melanoma characterized by dense fibrous stroma, resistance to chemotherapy and a lack of actionable driver mutations, but is highly associated with ultraviolet light DNA damage. We analysed 60 patients with advanced DM treated with programmed cell death 1 (PD-1) or PD-1 ligand (PD-L1) blocking antibody therapy. Objective...
- Subject
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CD8-Positive T-LymphocytesImmune Checkpoint InhibitorsMelanomaNeurofibromin 1Programmed Cell Death 1 Receptor
- Access Rights
- Application Required