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  • TMB and Immunotherapy (MSKCC, Nat Genet 2019): Genomic and survival data from 1661 tumor-normal pairs from 1661 patients with various cancer types sequenced with the MSK-IMPACT assay.

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of 1,661 samples of across multiple cancer types showing tumor mutational load and survival following immunotherapy from 1,661 patients. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK),...

    Subject
    DNA Mutational Analysis
    Immunotherapy
    Mutation
    Tumor Burden
    Access Rights
    Free to All
  • Skin Cutaneous Melanoma (TCGA, Firehose Legacy)

    Description

    TCGA Skin Cutaneous Melanoma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 480 carcinomas from 471 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information...

    Subject
    DNA Mutational Analysis
    Melanoma
    Skin Neoplasms
    Access Rights
    Free to All
  • Desmoplastic Melanoma (Broad Institute, Nat Genet 2015): Exome/Whole Genome sequencing of 20 desmoplastic melanoma tumor/normal pairs

    Description

    This dataset contains the summary data visualizations and clinical data of Exome/Whole Genome sequencing of 20 desmoplastic melanoma tumor/normal pairs. Clinical data includes: Mutation Count, Diagnosis Age, Anatomic Region, Detailed Sample Histology Category, Platform, Secondary Platform, Total Mutations, and Tumor Other Histologic Subtype. The plaintext components of the dataset can be downloaded...

    Subject
    Melanoma
    Skin Neoplasms
    Access Rights
    Free to All
  • Desmoplastic Melanoma

    Authors
    Shain, Alan H.
    Bastian, Boris C.
    Description

    Summary from the GEO: " High resolution aCGH was performed on 10 primary Desmoplastic Melanomas (DMs). DMs are a rare subtype of melanoma known for their pronounced desmoplastic stroma and spindled melanocytes. 10 samples were hybridized to Agilent 1 Million feature two color arrays as compared to a panel of normal male DNA. 6 samples were hybridized to Agilent 244K feature two color arrays as compared...

    Subject
    Melanoma
    Skin Neoplasms
    Access Rights
    Free to All
  • High response rate to anti PD-1 therapy in desmoplastic melanoma

    Authors
    Ribas, Antoni
    Description

    Study Description from dbGaP: Desmoplastic melanoma (DM) is a rare subtype of melanoma characterized by dense fibrous stroma, resistance to chemotherapy and a lack of actionable driver mutations, but is highly associated with ultraviolet light DNA damage. We analysed 60 patients with advanced DM treated with programmed cell death 1 (PD-1) or PD-1 ligand (PD-L1) blocking antibody therapy. Objective...

    Subject
    CD8-Positive T-Lymphocytes
    Immune Checkpoint Inhibitors
    Melanoma
    Neurofibromin 1
    Programmed Cell Death 1 Receptor
    Access Rights
    Application Required