This dataset contains summary data visualizations and clinical data from a broad sampling of 255 sarcomas from 255 patients. The data was gathered as part of the PanCancer Atlas initiative, which aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset. The clinical data includes mutation count, information about mutated genes,...

TCGA Sarcoma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 200 carcinomas from 200 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information about mutated...

This dataset contains the summary data visualizations and clinical data from Whole-exome sequencing of 206 Adult Soft Tissue Sarcoma tumor/normal pairs. from 206 patients. Clinical data includes: Cancer Type, Mutation Count, Fraction Genome Altered, Demographic Information, Adjuvant Postoperative Pharmaceutical Therapy Administered Indicator, AMP 12q15 CDK4, AMP 12q15 DDIT3, AMP 12q15 FRS2, AMP 12q15...

Description from GEO: "PRC2 loss of function occurs frequently in human MPNST. Here, we found that PRC2-loss tumors are separated from PRC2-wt ones at the transcriptome level by RNA-seq among 41 human MPNST tumor tissues." Overall design from GEO: "mRNA profiling of 41 human MPNST tumors including 15 PRC2-wt and 26 PRC2-loss tumors"

Description from GEO: "PRC2-isogenic human malignant peripheral nerve sheath tumor (MPNST) M3 cells were generated through CRISPR/Cas9-mediated knockout of the PRC2 core component, SUZ12. PRC2 loss led to not only significant increase, but also significant decrease of chromatin accessibility at 15,346 (16% of all ATAC peaks) and 20,099 genomic loci (21% of all ATAC peaks), respectively. PRC2 loss...

Description from GEO: "PRC2-isogenic human malignant peripheral nerve sheath tumor (MPNST) M3 cells were generated through CRISPR/Cas9-mediated knockout of the PRC2 core component, SUZ12. PRC2 loss leads to global loss of H3K27me3, which causes H3K27ac redistribution and also affect other histone modification, e.g., H3K36me2/3." Overall design from GEO: "PRC2-isogenic human MPNST M3 cells (sgCon,...