Summary from GEO: "The major cause for treatment failure, morbidity and mortality amongst medulloblastoma patients is metastasis intracranially or along the spinal cord. The molecular mechanisms driving tumor metastasis in SHH-driven medulloblastoma (SHH-MB) patients remain largely unknown. In this study we used mouse models of SHH-MB to define a tumor suppressive role of KMT2D (MLL4), a gene frequently...

Summary from GEO: "The major cause for treatment failure, morbidity and mortality amongst medulloblastoma patients is metastasis intracranially or along the spinal cord. The molecular mechanisms driving tumor metastasis in SHH-driven medulloblastoma (SHH-MB) patients remain largely unknown. In this study we used mouse models of SHH-MB to define a tumor suppressive role of KMT2D (MLL4), a gene frequently...

Whole genome or whole exome sequencing of 491 previously untreated Medulloblastoma tumor/normal pairs. The clinical data consists of 491 samples from 491 patients, and includes mutation count, structural variants, patient demographics, and tumor subtypes. The data set also includes charts visualizing data summaries and a customizable plotting tool.

Comprehensive profiling of 125 matched tumor and germline medulloblastoma samples from 125 patients. The clinical data includes a KM plot, information about survival status, mutation counts, and genomic profiles . The data set also includes charts visualizing data summaries and a customizable plotting tool.

Whole exome sequencing of 92 primary medulloblastoma tumor/normal pairs. The clinical data includes mutation count, information about mutated genes, mutation counts, TMB, and genomic profiles . The data set also includes charts visualizing data summaries and a customizable plotting tool.

Whole genome sequencing of 37 medulloblastoma tumors and their matched normals from the Pediatric Cancer Genome Project (PCGP), a joint project by St. Jude Children's Research Hospital and Washington University. The clinical data includes patient demographics, information about survival status, tumor cellularity dominant pathology reviews, and mutation counts. The data set also includes charts visualizing...

Whole-genome sequencing of 46 recurrent medulloblastoma samples from 46 patients. The clinical data includes patient demographics, structural variants, mutation counts, and a KM plot. The data set also includes charts visualizing data summaries and a customizable plotting tool.