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NCI-60 Cell Lines (NCI, Cancer Res 2012): Whole-exome sequencing of 67 samples by NCI-60 cell line project
- Description
This dataset contains summary data visualizations and clinical data from 67 samples from 67 patients as part an NCI-60 cell line project to compile NCI-60 cell line high-throughput and high-content data into CellMiner, a genomic and pharmacologic database created by the National Cancer Center Institute. The clinical data includes deidentified patient and sample IDs, mutation counts, detailed cancer...
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AdenocarcinomaBrain NeoplasmsBreast NeoplasmsCarcinoma, Renal CellColorectal NeoplasmsDNA Mutational AnalysisLeukemia, MyeloidLung NeoplasmsMelanomaOvarian NeoplasmsProstatic Neoplasms
- Access Rights
- Free to All
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Prostate Cancer (MSK, Cell Metab 2020): MSK-IMPACT Sequencing of 18 prostate cancer tumor/normal pairs.
- Description
This dataset contains summary data visualizations and clinical data from a sampling of 18 prostate tumor samples from 10 patients. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes deidentified patient and sample IDs, mutation count, and the fraction of genome that was altered. The data set also includes copy-number segment data downloadable as .seg...
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DNA Mutational AnalysisProstatic Neoplasms
- Access Rights
- Free to All
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Bladder Urothelial Carcinoma (TCGA, Firehose Legacy)
- Description
TCGA Bladder Urothelial Carcinoma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 413 carcinomas from 412 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information...
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DNA Mutational AnalysisProstatic NeoplasmsUrinary Bladder Neoplasms
- Access Rights
- Free to All
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RNA-seq analysis in NRG1 and enzalutamide treated 22Pc-EP cell line
- Authors
- Zhang, ZedaSawyers, Charles L.
- Description
Author summary from Gene Expression Omnibus: "Transcriptome prolifing analysis was performed in 22Pc-EP cells to identify differentially regulated genes by enzalutamide and NRG1. 22Pc-EP cells were treated with androgen receptor inhibition (enzalutamide) or a HER3 ligand NRG1 for 48hrs." The data is from a study on tumor microenvironment-derived NRG1 promotes antiandrogen resistance in prostate cancer.
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Prostatic Neoplasms
- Access Rights
- Free to All
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Gene expression analysis of primary mouse prostate organoid culture with overexpression of FOXA1
- Authors
- Adams, ElizabethSawyers, Charles L.Leslie, Christina
- Description
Summary from the GEO: "Gene expression analysis of primary mouse prostate organoid culture with overexpression of FOXA1 Examination by genotypes and days elapsed prepared in 3 replicates." The study associated with the dataset further explains FOXA1 and how it connects to the dataset: "Mutations in the transcription factor FOXA1 define a unique subset of prostate cancers but the functional consequences...
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ChromatinMutationProstatic Neoplasms
- Access Rights
- Free to All
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Chromatin Landscape Analysis of primary mouse prostate organoid culture with overexpression of FOXA1
- Authors
- Adams, ElizabethSawyers, Charles L.Leslie, Christina
- Description
Summary from the GEO: "Chromatin Landscape Analysis of primary mouse prostate organoid culture with overexpression of FOXA1. Examination by genotypes and days elapsed prepared in 3 replicates." This dataset depicts mutations in the FOXA1 gene, which define a unique subset of prostate cancers.
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ChromatinMutationProstatic Neoplasms
- Access Rights
- Free to All
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Validation of a genomic classifier that predicts metastasis following radical prostatectomy in at risk patient population
- Authors
- Karnes, R JeffreyBergstralh, Eric J.Davicioni, ElaiGhadessi, Mercedeh17 more author(s)...
- Description
Summary from the GEO: "Patients with locally advanced prostate cancer after radical prostatectomy are candidates for secondary therapy. However, this higher risk population is heterogeneous. Many cases do not metastasize even when conservatively managed. Given the limited specificity of pathological features to predict metastasis, newer risk prediction models are needed. We report a validation study...
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GenomicsProstatectomyProstatic Neoplasms
- Access Rights
- Free to All
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Discovery and validation of a prostate cancer genomic classifier that predicts early metastasis following radical prostatectomy
- Authors
- Erho, NicholasCrisan, AnamariaVergara, Ismael A.Mitra, Anirban P.15 more author(s)...
- Description
Summary from the GEO: "Clinicopathologic features and biochemical recurrence are sensitive, but not specific, predictors of metastatic disease and lethal prostate cancer. We hypothesize that a genomic expression signature detected in the primary tumor represents true biological potential of aggressive disease and provides improved prediction of early prostate cancer metastasis. Methods: A nested...
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MutationProstatectomyProstatic Neoplasms
- Access Rights
- Free to All
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Integrative genomic profiling of human prostate cancer
- Authors
- Taylor, Barry StephenSchultz, Nikolaus D.Hieronymus, HaleySawyers, Charles L.
- Description
GEO SuperSeries of expression profiling of prostatic neoplasms. This SuperSeries is composed of the SubSeries GSE21034, GSE21035, and GSM525577. Each one concerns measuring prostate cancer genomes and different arrays of expression data, including DNA copy number, mRNA and microRNA. The prostate tumor samples originated from 218 patients. Each dataset in the SubSeries share the same description:...
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MutationProstatic Neoplasms
- Access Rights
- Free to All
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A genomic classifier improves prediction of metastatic disease within 5 years after surgery in node-negative high-risk prostate cancer patients managed by radical prostatectomy without adjuvant therapy
- Authors
- Klein, Eric A.Yousefi, KasraHaddad, ZaidChoeurng, Voleak6 more author(s)...
- Description
Summary from the GEO: "To determine whether adding Decipher to standard risk stratification tools (CAPRA-S and Stephenson nomogram) improves accuracy in prediction of metastatic disease within 5 years after surgery in men with adverse pathologic features after RP. The study population consisted of 182 patients selected from 2,641 men who underwent RP at the Cleveland Clinic between 1987-2008 who...
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ProstatectomyProstatic Neoplasms
- Access Rights
- Free to All