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Results Found: 36
  • NCI-60 Cell Lines (NCI, Cancer Res 2012): Whole-exome sequencing of 67 samples by NCI-60 cell line project

    Description

    This dataset contains summary data visualizations and clinical data from 67 samples from 67 patients as part an NCI-60 cell line project to compile NCI-60 cell line high-throughput and high-content data into CellMiner, a genomic and pharmacologic database created by the National Cancer Center Institute. The clinical data includes deidentified patient and sample IDs, mutation counts, detailed cancer...

    Subject
    Adenocarcinoma
    Brain Neoplasms
    Breast Neoplasms
    Carcinoma, Renal Cell
    Colorectal Neoplasms
    DNA Mutational Analysis
    Leukemia, Myeloid
    Lung Neoplasms
    Melanoma
    Ovarian Neoplasms
    Prostatic Neoplasms
    Access Rights
    Free to All
  • Prostate Cancer (MSK, Cell Metab 2020): MSK-IMPACT Sequencing of 18 prostate cancer tumor/normal pairs.

    Description

    This dataset contains summary data visualizations and clinical data from a sampling of 18 prostate tumor samples from 10 patients. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes deidentified patient and sample IDs, mutation count, and the fraction of genome that was altered. The data set also includes copy-number segment data downloadable as .seg...

    Subject
    DNA Mutational Analysis
    Prostatic Neoplasms
    Access Rights
    Free to All
  • Bladder Urothelial Carcinoma (TCGA, Firehose Legacy)

    Description

    TCGA Bladder Urothelial Carcinoma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 413 carcinomas from 412 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information...

    Subject
    DNA Mutational Analysis
    Prostatic Neoplasms
    Urinary Bladder Neoplasms
    Access Rights
    Free to All
  • RNA-seq analysis in NRG1 and enzalutamide treated 22Pc-EP cell line

    Authors
    Zhang, Zeda
    Sawyers, Charles L.
    Description

    Author summary from Gene Expression Omnibus: "Transcriptome prolifing analysis was performed in 22Pc-EP cells to identify differentially regulated genes by enzalutamide and NRG1. 22Pc-EP cells were treated with androgen receptor inhibition (enzalutamide) or a HER3 ligand NRG1 for 48hrs." The data is from a study on tumor microenvironment-derived NRG1 promotes antiandrogen resistance in prostate cancer.

    Subject
    Prostatic Neoplasms
    Access Rights
    Free to All
  • Gene expression analysis of primary mouse prostate organoid culture with overexpression of FOXA1

    Authors
    Adams, Elizabeth
    Sawyers, Charles L.
    Leslie, Christina
    Description

    Summary from the GEO: "Gene expression analysis of primary mouse prostate organoid culture with overexpression of FOXA1 Examination by genotypes and days elapsed prepared in 3 replicates." The study associated with the dataset further explains FOXA1 and how it connects to the dataset: "Mutations in the transcription factor FOXA1 define a unique subset of prostate cancers but the functional consequences...

    Subject
    Chromatin
    Mutation
    Prostatic Neoplasms
    Access Rights
    Free to All
  • Chromatin Landscape Analysis of primary mouse prostate organoid culture with overexpression of FOXA1

    Authors
    Adams, Elizabeth
    Sawyers, Charles L.
    Leslie, Christina
    Description

    Summary from the GEO: "Chromatin Landscape Analysis of primary mouse prostate organoid culture with overexpression of FOXA1. Examination by genotypes and days elapsed prepared in 3 replicates." This dataset depicts mutations in the FOXA1 gene, which define a unique subset of prostate cancers.

    Subject
    Chromatin
    Mutation
    Prostatic Neoplasms
    Access Rights
    Free to All
  • Validation of a genomic classifier that predicts metastasis following radical prostatectomy in at risk patient population

    Authors
    Karnes, R Jeffrey
    Bergstralh, Eric J.
    Davicioni, Elai
    Ghadessi, Mercedeh
    17 more author(s)...
    Description

    Summary from the GEO: "Patients with locally advanced prostate cancer after radical prostatectomy are candidates for secondary therapy. However, this higher risk population is heterogeneous. Many cases do not metastasize even when conservatively managed. Given the limited specificity of pathological features to predict metastasis, newer risk prediction models are needed. We report a validation study...

    Subject
    Genomics
    Prostatectomy
    Prostatic Neoplasms
    Access Rights
    Free to All
  • Discovery and validation of a prostate cancer genomic classifier that predicts early metastasis following radical prostatectomy

    Authors
    Erho, Nicholas
    Crisan, Anamaria
    Vergara, Ismael A.
    Mitra, Anirban P.
    15 more author(s)...
    Description

    Summary from the GEO: "Clinicopathologic features and biochemical recurrence are sensitive, but not specific, predictors of metastatic disease and lethal prostate cancer. We hypothesize that a genomic expression signature detected in the primary tumor represents true biological potential of aggressive disease and provides improved prediction of early prostate cancer metastasis. Methods: A nested...

    Subject
    Mutation
    Prostatectomy
    Prostatic Neoplasms
    Access Rights
    Free to All
  • Integrative genomic profiling of human prostate cancer

    Authors
    Taylor, Barry Stephen
    Schultz, Nikolaus D.
    Hieronymus, Haley
    Sawyers, Charles L.
    Description

    GEO SuperSeries of expression profiling of prostatic neoplasms. This SuperSeries is composed of the SubSeries GSE21034, GSE21035, and GSM525577. Each one concerns measuring prostate cancer genomes and different arrays of expression data, including DNA copy number, mRNA and microRNA. The prostate tumor samples originated from 218 patients. Each dataset in the SubSeries share the same description:...

    Subject
    Mutation
    Prostatic Neoplasms
    Access Rights
    Free to All
  • A genomic classifier improves prediction of metastatic disease within 5 years after surgery in node-negative high-risk prostate cancer patients managed by radical prostatectomy without adjuvant therapy

    Authors
    Klein, Eric A.
    Yousefi, Kasra
    Haddad, Zaid
    Choeurng, Voleak
    6 more author(s)...
    Description

    Summary from the GEO: "To determine whether adding Decipher to standard risk stratification tools (CAPRA-S and Stephenson nomogram) improves accuracy in prediction of metastatic disease within 5 years after surgery in men with adverse pathologic features after RP. The study population consisted of 182 patients selected from 2,641 men who underwent RP at the Cleveland Clinic between 1987-2008 who...

    Subject
    Prostatectomy
    Prostatic Neoplasms
    Access Rights
    Free to All