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SUMMIT - Neratinib Basket Study (Multi-Institute, Nature 2018): MSK-IMPACT sequencing of 86 patients with HER2- and HER3-mutant cancers
- Description
This dataset contains summary data visualizations and clinical data from a broad sampling of HER2- and HER3-mutant tumors. The data was generated utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, Amplification Status, Best objective response rate, Bubble...
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Breast NeoplasmsCarcinoma, HepatocellularCarcinoma, Non-Small-Cell LungCarcinoma, Renal CellColorectal NeoplasmsDNA Mutational AnalysisEndometrial NeoplasmsEsophageal NeoplasmsGenes, erbBGenes, erbB-2MelanomaOvarian NeoplasmsPancreatic NeoplasmsSalivary Gland NeoplasmsSarcomaSkin NeoplasmsUrinary Bladder NeoplasmsUterine Cervical Neoplasms
- Access Rights
- Free to All
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TMB and Immunotherapy (MSKCC, Nat Genet 2019): Genomic and survival data from 1661 tumor-normal pairs from 1661 patients with various cancer types sequenced with the MSK-IMPACT assay.
- Description
This dataset contains summary data visualizations and clinical data from a broad sampling of 1,661 samples of across multiple cancer types showing tumor mutational load and survival following immunotherapy from 1,661 patients. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK),...
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DNA Mutational AnalysisImmunotherapyMutationTumor Burden
- Access Rights
- Free to All
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NCI-60 Cell Lines (NCI, Cancer Res 2012): Whole-exome sequencing of 67 samples by NCI-60 cell line project
- Description
This dataset contains summary data visualizations and clinical data from 67 samples from 67 patients as part an NCI-60 cell line project to compile NCI-60 cell line high-throughput and high-content data into CellMiner, a genomic and pharmacologic database created by the National Cancer Center Institute. The clinical data includes deidentified patient and sample IDs, mutation counts, detailed cancer...
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AdenocarcinomaBrain NeoplasmsBreast NeoplasmsCarcinoma, Renal CellColorectal NeoplasmsDNA Mutational AnalysisLeukemia, MyeloidLung NeoplasmsMelanomaOvarian NeoplasmsProstatic Neoplasms
- Access Rights
- Free to All
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Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma
- Description
Summary from BioProject: "Renal medullary carcinoma (RMC) is a highly lethal malignancy that mainly afflicts young individuals of African descent and is resistant to all targeted agents used to treat other renal cell carcinomas. Comprehensive genomic and transcriptomic profiling of untreated primary RMC tissues was performed to elucidate the molecular landscape of these tumors. We found that RMC was...
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Carcinoma, MedullaryCarcinoma, Renal CellKidney Neoplasms
- Access Rights
- Free to All
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Unclassified Renal Cell Carcinoma (MSK, Nature 2016): Targeted sequencing of 62 high-grade primary Unclassified Renal Cell Carcinoma tumor samples with matched normals.
- Description
This dataset contains the summary data visualizations and clinical data from targeted sequencing of 62 high-grade primary Unclassified Renal Cell Carcinoma tumor samples with matched normals from 62 patients. Clinical data includes: Mutation Count, Fraction Genome Altered, Demographic Information, AJCC Metastasis Stage Code, AJCC Tumor Stage Code, Disease Surgical Margin Status, Gene Panel, Last Status,...
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AdenocarcinomaCarcinoma, Renal Cell
- Access Rights
- Free to All
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Molecular analysis of renal cell carcinoma with unclassfied histology [copy number alterations]
- Authors
- Chen, YingbeiWang, LuZhao, Jeffrey
- Description
Summary from the GEO: "Renal cell carcinomas with unclassified histology (uRCC) constitute a significant portion of aggressive non-clear cell RCC (nccRCC) that have no standard therapy. The oncogenic drivers in these tumors are unknown. We performed a molecular analysis of 62 high-grade primary uRCC, incorporating targeted cancer gene sequencing, RNA sequencing, Single Nucleotide Polymorphism array,...
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Carcinoma, Renal Cell
- Access Rights
- Free to All
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Molecular analysis of renal cell carcinoma with unclassfied histology [gene expression]
- Authors
- Chen, YingbeiSkanderup, Anders J.Reuter, VictorHsieh, James J.1 more author(s)...
- Description
Summary from the GEO: "Renal cell carcinomas with unclassified histology (uRCC) constitute a significant portion of aggressive non-clear cell RCC (nccRCC) that have no standard therapy. The oncogenic drivers in these tumors are unknown. We performed a molecular analysis of 62 high-grade primary uRCC, incorporating targeted cancer gene sequencing, RNA sequencing, Single Nucleotide Polymorphism array,...
- Subject
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Carcinoma, Renal Cell
- Access Rights
- Free to All