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Results Found: 3
  • Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer

    Authors
    Hollingsworth, Louis R.
    David, Liron
    Li, Yang
    Ruan, Jianbin
    1 more author(s)...
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the cryo-EM structure of CARD8-CARD filament. The main summary display for this entry includes information on the experimental method, validation and macromolecules in the deposit, as well as entry history and funding information. Data is provided...

    Subject
    Adaptor Proteins, Signal Transducing
    Amino Acid Transport System ASC
    Ankyrins
    Apoptosis
    Caspase 1
    Caspase Activation and Recruitment Domain
    Death Domain Receptor Signaling Adaptor Proteins
    Inflammasomes
    Neoplasm Proteins
    NLR Family, Pyrin Domain-Containing 3 Protein
    NLR Proteins
    Access Rights
    Free to All
  • Cryo-EM structure of the NLRP1-CARD filament

    Authors
    Hollingsworth, Louis R.
    David, Liron
    Li, Yang
    Sharif, Humayun
    3 more author(s)...
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the cryo-EM structure of the NLRP1-CARD filament. The main summary display for this entry includes information on the experimental method, validation and macromolecules in the deposit, as well as entry history and funding information. Data is provided...

    Subject
    Adaptor Proteins, Signal Transducing
    Ankyrins
    Apoptosis
    Apoptosis Regulatory Proteins
    CARD Signaling Adaptor Proteins
    Caspase 1
    Caspase Activation and Recruitment Domain
    Death Domain Receptor Signaling Adaptor Proteins
    Inflammasomes
    Neoplasm Proteins
    NLR Proteins
    Access Rights
    Free to All
  • ANKRD31 protein interactions

    Authors
    Li, Zhuoning
    Keeney, Scott
    Description

    Description from PRIDE: "Sex chromosomes in males of most mammalian species share only a small homologous segment, the pseudoautosomal region (PAR), wherein double-strand break (DSB) formation must occur for correct meiotic segregation. We find that multiple DSB-promoting factors hyperaccumulate in the PAR, including the ankyrin-repeat domain-containing protein ANKRD31. We used immunoprecipitation...

    Subject
    Ankyrins
    DNA Breaks, Double-Stranded
    Mass spectrometry
    Pseudoautosomal Regions
    Sex Characteristics
    Access Rights
    Free to All