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Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer
- Authors
- Hollingsworth, Louis R.David, LironLi, YangRuan, Jianbin1 more author(s)...
- Description
This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the cryo-EM structure of CARD8-CARD filament. The main summary display for this entry includes information on the experimental method, validation and macromolecules in the deposit, as well as entry history and funding information. Data is provided...
- Subject
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Adaptor Proteins, Signal TransducingAmino Acid Transport System ASCAnkyrinsApoptosisCaspase 1Caspase Activation and Recruitment DomainDeath Domain Receptor Signaling Adaptor ProteinsInflammasomesNeoplasm ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinNLR Proteins
- Access Rights
- Free to All
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Cryo-EM structure of the NLRP1-CARD filament
- Authors
- Hollingsworth, Louis R.David, LironLi, YangSharif, Humayun3 more author(s)...
- Description
This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the cryo-EM structure of the NLRP1-CARD filament. The main summary display for this entry includes information on the experimental method, validation and macromolecules in the deposit, as well as entry history and funding information. Data is provided...
- Subject
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Adaptor Proteins, Signal TransducingAnkyrinsApoptosisApoptosis Regulatory ProteinsCARD Signaling Adaptor ProteinsCaspase 1Caspase Activation and Recruitment DomainDeath Domain Receptor Signaling Adaptor ProteinsInflammasomesNeoplasm ProteinsNLR Proteins
- Access Rights
- Free to All
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ANKRD31 protein interactions
- Authors
- Li, ZhuoningKeeney, Scott
- Description
Description from PRIDE: "Sex chromosomes in males of most mammalian species share only a small homologous segment, the pseudoautosomal region (PAR), wherein double-strand break (DSB) formation must occur for correct meiotic segregation. We find that multiple DSB-promoting factors hyperaccumulate in the PAR, including the ankyrin-repeat domain-containing protein ANKRD31. We used immunoprecipitation...
- Subject
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AnkyrinsDNA Breaks, Double-StrandedMass spectrometryPseudoautosomal RegionsSex Characteristics
- Access Rights
- Free to All