Summary from GEO: "Large deletions in mitochondrial DNA (mtDNA) have been linked to a variety of clinical pathologies, including somatic emergence in congenital disorders such as Pearson Syndrome (MIM:557000), a mitochondrial disease characterized by sideroblastic anemia and exocrine pancreas dysfunction. Here, we develop a multi-omics approach to quantify mtDNA deletion heteroplasmy and cell state...

Summary from GEO: "Meninges, or the membranous coverings of the brain and spinal cord, play host to dozens of morbid pathologies. In this study we provide a method to isolate the leptomeningeal cell layer, identify leptomeninges in histologic slides, and maintain leptomeningeal fibroblasts in in vitro culture. Using an array of transcriptomic, histological, and cytometric analyses, we identified...

Description from Figshare: "scRNA-seq time-series dataset of mouse embryonic fibroblast (MEF) reprogramming to induced pluripotent stem cells (iPSCs) subsetted to the serum condition and assayed using 10x Genomics. Contains 39 time points spanning days 0-18 during reprogramming. Total cell number is 165,892. Note that this dataset has already been normalized by total counts and log-transformed....

Description from Figshare: "scRNA-seq time-series dataset of mouse embryonic fibroblast (MEF) reprogramming to induced endoderm progenitors (iEPs) assayed using Dropseq and 10x Genomics. Contains 8 time points spanning days 0-28 during reprogramming. Total cell number is 104,887. This dataset contains raw spliced and unspliced counts estimated using the velocyto pipeline (La Manno et al., Nature...