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  • Discovery of a Drug Candidate for GLIS3-Associated Diabetes

    Authors
    Amin, Sadaf
    Cook, Brandoch
    Zhou, Ting
    Ghazizadeh, Zaniar
    13 more author(s)...
    Description

    Comparison of WT and GLIS3-/- cells at various stages of human pancreatic differentiation. From Gene Expression Omnibus authors' summary: "Through development and use of a minimal component protocol for derivation of late stage pancreatic progenitors and beta-like cells, we compared WT and GLIS3-/- pancreatic cells at different stages and discovered that GLIS3-/- cells show an ectopic activation...

    Subject
    Cell Differentiation/genetics
    Diabetes Mellitus
    Human Embryonic Stem Cells
    Hypoglycemic Agents
    Insulin-Secreting Cells
    Transcription Factors
    Access Rights
    Free to All
  • Directed differentiation of oligodendrocytes from human embryonic stem cells

    Authors
    Major, Tamara
    Tabar, Viviane S
    Description

    Summary from GEO: "Here we compare the transcriptional profile of the undifferentiated hESC with the anterior oligodendroctes derived from the hESC using our new differentiation protocol." Overall design from GEO: "Total RNA was isolated from undifferentiated hES cells and from hES derived oligodendrocytes, 70 days old and FACS sorted for O4 marker. Samples for each group in triplicate were...

    Subject
    Cell Differentiation
    Genomics
    Human Embryonic Stem Cells
    Oligodendroglia
    Access Rights
    Free to All