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  • MeRIP-seq mapping of m6A in the IFN-β induced transcriptome in Huh7 cells

    Authors
    McFadden, Michael J.
    McIntyre, Alexa B R
    Gokhale, Nandan S.
    Mason, Christopher E
    1 more author(s)...
    Description

    Summary from the GEO: "The RNA modification N6-methyladenosine (m6A) regulates gene expression through various transcript-specific effects. The goal of this experiment was to identify m6A-modified transcripts during the type I interferon response, with interest in determining which interferon-stimulated genes are modified by m6A. We found that a high percentage of ISGs are m6A-modified, and in follow-up...

    Subject
    Gene Expression
    Interferon Type I
    Interferons
    Transcription Factors
    Access Rights
    Free to All
  • Genetic ancestry effects on the response to viral infection are pervasive but cell type specific

    Authors
    Randolph, Haley E.
    Description

    Description from BioProject: "Humans differ in their susceptibility to infectious disease, partly due to variation in the immune response following infection. We used single-cell RNA-sequencing to quantify variation in the response to influenza infection in peripheral blood mononuclear cells from European- and African-ancestry males. Genetic ancestry effects are common but highly cell type-specific....

    Subject
    Immunity, Active
    Influenza, Human
    Interferon Type I
    Single-Cell Gene Expression Analysis
    Viral Infections
    Access Rights
    Free to All