Summary from the GEO: "Linker histone H1 proteins bind to nucleosomes and cause chromatin compaction, although little is known about their biological functions. Histone H1 (HIST1H1B-E) mutations are highly recurrent in B-cell lymphomas and are present in solid tumors, but their cancer relevance and mechanism are unknown. Here we report that lymphoma-associated H1 alleles are genetic driver mutations...

This Dataset is a SuperSeries composed of the following SubSeries: GSE79639 Loss of CREBBP results in H3K27ac loss at enhancers in lymphoma cells GSE79640 Loss of CREBBP results in H3K27ac loss at enhancers in mouse lymphoma cells GSE79684 Loss of CREBBP results in gene expression repression in lymphoma cells GSE79685 Loss of CREBBP results in gene expression represssion in mouse lymphoma cells...

Summary from the GEO: "KD of CREBBP at lymphoma cell line, MD901, results in reduced expression. Genome-wide profiling of total RNA transcript levels in human cell line MD901 (CREBBP wild type) with shCREBBP and scramble control." The associated article further explains the study and shows how the dataset is connected: "Somatic mutations in CREBBP occur frequently in B-cell lymphoma. Here, we show...

Summary from the GEO: "KD of CREBBP at lymphoma cell line, MD901, results in reduced H3K27ac enrichment at a subset of promoters and enhancers. Genome-wide H3K27Ac ChIPseq binding sites in human cell line MD901 (CREBBP wild type) with shCREBBP (11027 and 3752) and scramble control."

Summary from the GEO: "KD of Crebbp at mouse cells results in reduced H3K27ac enrichment at a subset of promoters and enhancers. Genome-wide H3K27Ac ChIPseq binding sites in mouse cells with shCrebbp and scramble control."

Summary from the GEO: 'KD of Crebbp at mouse cells results in reduced expression. Genome-wide profiling of total RNA transcript levels in in mouse cells with shCrebbp and scramble control."