This dataset contains summary data visualizations and clinical data from a comprehensive genomic and transcriptomic analysis of 38 acral lentiginous melanomas (ALM) from 34 patients. The study was conducted to analyze ALM, a rare sun-shielded melanoma subtype of cutaneous melanoma (CM) which is associated with worse survival than other CM in an effort to delineate non-UV oncogenic mechanisms. The...

From the dbGaP study description: "In this study, we performed paired tumor/normal long insert whole genome and exome sequencing and tumor RNA sequencing on primary or metastatic acral melanoma tumors collected from 34 patients. Patients were enrolled from either Vanderbilt University or the Memorial Sloan-Kettering Cancer Center. We report an integrated analysis of DNA and RNA sequencing data to...

Dataset III and dictionary III. Excel spreadsheet and Data Dictionary that contain information on tissue samples of suspected Melanoma cases including specimens such as presence of tumor, tissue source and other relevant tissue information relevant to genomic analysis.

Dataset I and dictionary I. Excel spreadsheet and Data Dictionary that contain information on tissue samples of suspected Melanoma cases including specimens such as presence of tumor, tissue source and other relevant tissue information relevant to genomic analysis.

Dataset II and dictionary II. Excel spreadsheet and Data Dictionary that contain information on tissue samples of suspected Melanoma cases including specimens such as presence of tumor, tissue source and other relevant tissue information relevant to genomic analysis.

Summary from GEO: "Broadly we were interested in understanding how fin and body melanocytes were different. The goal of the experiment was to investigate the interaction between three different variables: (1) cell lineage: melanocyte vs bulk microenvironment, (2) anatomic location: fin vs body, (3) genotype: wildtype vs CRKL,GAB2,TERT overexpression with NF1 loss. We found that melanocytes have unique...