Summary from GEO: "Oncogenes can only initiate tumors in certain cellular contexts, which is referred to as oncogenic competence. In melanoma, whether cells in the microenvironment can endow such competence remains unclear. Using a combination of zebrafish transgenesis coupled with human tissues, we demonstrate that GABAergic signaling between keratinocytes and melanocytes promotes melanoma initiation...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes electron microscopy data identifying the NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (1:1 binding mode). The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit,...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes electron microscopy data identifying the NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (2:1 binding mode). The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit,...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes electron microscopy data identifying NSD2 bearing E1099K/T1150A dual mutation in complex with 187-bp NCP. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history and...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes electron microscopy data identifying native NSD3 bound to 187-bp nucleosome. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history and funding identification. Data...

Cross-linking mass spectrometry data for integrative structural analyses of the Smc5/6 holo-complex from budding yeast. Electron microscopy, crosslinking mass spectrometry, and computational modeling reveal that while the complex shares an overall organization with other SMC complexes, it possesses several strikingly different features.