13 supplementary tables supporting "Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma." The contents of the tables are as follows: Table S1: Differential H3K27Ac in CREBBP-WT vs CREBBP-R1446C Table S2: Differentially expressed genes in CREBBP-WT vs CREBBP-R1446C Table S3: Hypergeometric gene set enrichment analysis of differential H3K27Ac...

Summary from GEO: "CREBBP mutations are highly recurrent in B-cell lymphomas and either inactivate its histone acetyltransferase (HAT) domain or truncate the protein. Herein, we show that these two classes of mutations yield different degrees of disruption of the epigenome, with HAT mutations being more severe and associated with inferior clinical outcome. Genes perturbed by CREBBP mutation are direct...

Description from Figshare: "Supplementary Table 4: Complete list of mutations and copy number alterations detected by MSK-IMPACT in 45 LCNECs"

Description from Figshare: "Supplementary Table 5: Detailed summary of NOTCH gene family mutations"

Description from Figshare: "Supplementary Table 6: Complete list of potentially-actionable alterations"

Summary from GEO: "Glioma CIMP (G-CIMP) is a powerful determinant of tumor pathogenicity but the molecular cause of G-CIMP is a fundamental question that is unresolved. Here, we show that mutation of a single gene, isocitrate dehydrogenase 1 (IDH1), directly causes the G-CIMP in gliomas by remodeling the methylome." Overall design from GEO: "In this study 52 glioma clinic samples (36 CIMP+ and...

Summary from GEO: "Glioma CIMP (G-CIMP) is a powerful determinant of tumor pathogenicity but the molecular cause of G-CIMP is a fundamental question that is unresolved. Here, we show that mutation of a single gene, isocitrate dehydrogenase 1 (IDH1), directly causes the G-CIMP in gliomas by remodeling the methylome." Overall design from GEO: "In this study 81 glioma clinic samples (49 CIMP+ and...

Clonal hematopoiesis mutations identified in blood samples from patients whose tumor-blood pairs were analyzed using MSK-IMPACT. The clinical data includes mutation count, information about mutated genes, patient demographics, and information about treatment. The data set also includes charts visualizing data summaries and customizable plotting tool.

Whole genome or whole exome sequencing of 491 previously untreated Medulloblastoma tumor/normal pairs. The clinical data consists of 491 samples from 491 patients, and includes mutation count, structural variants, patient demographics, and tumor subtypes. The data set also includes charts visualizing data summaries and a customizable plotting tool.

Comprehensive profiling of 125 matched tumor and germline medulloblastoma samples from 125 patients. The clinical data includes a KM plot, information about survival status, mutation counts, and genomic profiles . The data set also includes charts visualizing data summaries and a customizable plotting tool.