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  • TMEM41B is a pan-flavivirus host factor

    Authors
    Hoffmann, H.-Heinrich
    Schneider, William M.
    Rozen-Gagnon, Kathryn
    Miles, Linde A.
    10 more author(s)...
    Description

    Summary from the GEO: "Flaviviruses pose a constant threat to human health. These RNA viruses are transmitted by the bite of infected mosquitoes and ticks and regularly cause outbreaks. To identify host factors required for flavivirus infection we performed full-genome loss of function CRISPR-Cas9 screens. Based on these results we focused our efforts on characterizing the roles that TMEM41B and VMP1...

    Subject
    CRISPR-Cas Systems
    Flavivirus
    Flavivirus Infections
    Membrane Proteins
    Polymorphism, Single Nucleotide
    Virus Replication
    Access Rights
    Free to All
  • Genome-wide association study for Bladder Cancer Risk

    Authors
    Rothman, Nathaniel
    Garcia-Closas, Montserrat
    Silverman, Debra
    Chanock, Stephen
    18 more author(s)...
    Description

    Description from dbGaP: "This study funded by the National Cancer Institute (NCI) involves conducting a genome-wide association study of common genetic variants to identify markers of susceptibility to bladder cancer. This bladder GWAS has led to the discovery of three novel regions in the genome associated with bladder cancer risk. Cases were defined as individuals having histologically confirmed...

    Subject
    Genome-Wide Association Study
    Genomics
    Neoplasms/genetics
    Polymorphism, Single Nucleotide
    Urinary Bladder Neoplasms
    Access Rights
    Application Required