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(Metabolome analysis data): Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway
- Authors
- Kitamura, Toshio
- Description
Description from MassIVE: Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations drive CH remains elusive. Using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT), we examined the influence of ASXL1-MT on physiological aging in hematopoietic stem cells (HSCs). HSCs expressing ASXL1-MT display competitive...
- Subject
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Clonal HematopoiesisHematopoietic Stem CellsMetabolomeMyelodysplastic Syndromes
- Access Rights
- Free to All
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Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway
- Description
Summary from BioProject: "Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations drive CH remains elusive. Using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT), we examined the influence of ASXL1-MT on physiological aging in hematopoietic stem cells (HSCs). HSCs expressing ASXL1-MT display competitive...
- Subject
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Clonal HematopoiesisHematopoietic Stem CellsProto-Oncogene Proteins c-aktRepressor Proteins
- Access Rights
- Free to All
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MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
- Authors
- Wei, QiaozhiFrenette, Paul S.
- Description
Summary from the GEO: "Haematopoietic stem cells (HSCs) tightly regulate their quiescence, proliferation, and differentiation to generate blood cells during the entire lifetime. The mechanisms by which these critical activities are balanced are still unclear. Here, we report that Macrophage-Erythroblast Attacher (MAEA, also known as EMP), a receptor thus far only identified in erythroblastic island1,...
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Cell Adhesion MoleculesCytoskeletal ProteinsGene Expression ProfilingHematopoiesisHematopoietic Stem CellsLeukemia, Myeloid, AcuteLymphokinesUbiquitin-Protein Ligases
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- Free to All
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Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LSK and LK)
- Authors
- Kharas, Michael G.Lengner, Christopher J.Al-Shahrour, FatimaBullinger, Lars16 more author(s)...
- Description
Summary from the GEO: "We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressive leukemia. MSI2 is over-expressed in human myeloid leukemia, and expression...
- Subject
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Hematopoietic Stem CellsLeukemia
- Access Rights
- Free to All