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  • (Metabolome analysis data): Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway

    Authors
    Kitamura, Toshio
    Description

    Description from MassIVE: Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations drive CH remains elusive. Using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT), we examined the influence of ASXL1-MT on physiological aging in hematopoietic stem cells (HSCs). HSCs expressing ASXL1-MT display competitive...

    Subject
    Clonal Hematopoiesis
    Hematopoietic Stem Cells
    Metabolome
    Myelodysplastic Syndromes
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  • Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway

    Description

    Summary from BioProject: "Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations drive CH remains elusive. Using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT), we examined the influence of ASXL1-MT on physiological aging in hematopoietic stem cells (HSCs). HSCs expressing ASXL1-MT display competitive...

    Subject
    Clonal Hematopoiesis
    Hematopoietic Stem Cells
    Proto-Oncogene Proteins c-akt
    Repressor Proteins
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  • MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells

    Authors
    Wei, Qiaozhi
    Frenette, Paul S.
    Description

    Summary from the GEO: "Haematopoietic stem cells (HSCs) tightly regulate their quiescence, proliferation, and differentiation to generate blood cells during the entire lifetime. The mechanisms by which these critical activities are balanced are still unclear. Here, we report that Macrophage-Erythroblast Attacher (MAEA, also known as EMP), a receptor thus far only identified in erythroblastic island1,...

    Subject
    Cell Adhesion Molecules
    Cytoskeletal Proteins
    Gene Expression Profiling
    Hematopoiesis
    Hematopoietic Stem Cells
    Leukemia, Myeloid, Acute
    Lymphokines
    Ubiquitin-Protein Ligases
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  • Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LSK and LK)

    Authors
    Kharas, Michael G.
    Lengner, Christopher J.
    Al-Shahrour, Fatima
    Bullinger, Lars
    16 more author(s)...
    Description

    Summary from the GEO: "We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressive leukemia. MSI2 is over-expressed in human myeloid leukemia, and expression...

    Subject
    Hematopoietic Stem Cells
    Leukemia
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