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Results Found: 7
  • Sarcoma (TCGA, PanCancer Atlas)

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of 255 sarcomas from 255 patients. The data was gathered as part of the PanCancer Atlas initiative, which aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset. The clinical data includes mutation count, information about mutated genes,...

    Subject
    DNA Mutational Analysis
    Fibromatosis, Aggressive
    Fibrosarcoma
    Histiocytoma, Malignant Fibrous
    Leiomyosarcoma
    Liposarcoma
    Nerve Sheath Neoplasms
    Neurofibroma
    Sarcoma
    Sarcoma, Synovial
    Access Rights
    Free to All
  • MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017): Targeted sequencing of 10,000 clinical cases using the MSK-IMPACT assay

    Description

    This dataset contains summary data visualizations and clinical data from the targeted sequencing of 10,000 clinical cases using the MSK-IMPACT assay. The clinical data includes mutation count, information about mutated genes, tumor mutational burden calculations, tissue site from which the sample was derived, tumor purity among other relevant data points. The data set also includes copy-number segment...

    Subject
    Adenocarcinoma
    Adenocarcinoma of Lung
    Adenocarcinoma, Mucinous
    Breast Neoplasms
    Carcinoma, Ductal, Breast
    Carcinoma, Hepatocellular
    Carcinoma, Lobular
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Renal Cell
    Carcinoma, Squamous Cell
    Carcinosarcoma
    Cholangiocarcinoma
    Colonic Neoplasms
    Colorectal Neoplasms
    Cystadenocarcinoma, Serous
    DNA Mutational Analysis
    Gallbladder Neoplasms
    Glioblastoma
    Liposarcoma
    Lung Neoplasms
    Lymphoma, Follicular
    Melanoma
    Mesothelioma
    Neoplasms, Squamous Cell
    Neurofibroma
    Oligodendroglioma
    Osteosarcoma
    Ovarian Neoplasms
    Pancreatic Neoplasms
    Prostatic Neoplasms
    Rectal Neoplasms
    Sarcoma
    Sarcoma, Synovial
    Squamous Cell Carcinoma of Head and Neck
    Stomach Neoplasms
    Thyroid Cancer, Papillary
    Urinary Bladder Neoplasms
    Uterine Neoplasms
    Uveal Neoplasms
    Access Rights
    Free to All
  • Sarcoma (TCGA, Firehose Legacy)

    Description

    TCGA Sarcoma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 200 carcinomas from 200 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information about mutated...

    Subject
    DNA Mutational Analysis
    Fibromatosis, Aggressive
    Fibrosarcoma
    Histiocytoma, Malignant Fibrous
    Leiomyosarcoma
    Liposarcoma
    Nerve Sheath Neoplasms
    Neurofibroma
    Sarcoma
    Sarcoma, Synovial
    Access Rights
    Free to All
  • Adult Soft Tissue Sarcomas (TCGA, Cell 2017): Whole-exome sequencing of 206 Adult Soft Tissue Sarcoma tumor/normal pairs.

    Description

    This dataset contains the summary data visualizations and clinical data from Whole-exome sequencing of 206 Adult Soft Tissue Sarcoma tumor/normal pairs. from 206 patients. Clinical data includes: Cancer Type, Mutation Count, Fraction Genome Altered, Demographic Information, Adjuvant Postoperative Pharmaceutical Therapy Administered Indicator, AMP 12q15 CDK4, AMP 12q15 DDIT3, AMP 12q15 FRS2, AMP 12q15...

    Subject
    Histiocytoma, Malignant Fibrous
    Leiomyosarcoma
    Liposarcoma
    Lymphoma, Non-Hodgkin
    Neurofibrosarcoma
    Sarcoma
    Sarcoma, Synovial
    Access Rights
    Free to All
  • Therapy-induced senescence contributes to the efficacy of abemaciclib in patients with dedifferentiated liposarcoma

    Authors
    Dooley, Mary E. Klein
    Koff, Andrew C.
    Description

    Summary from GEO: "Current research on CDK4/6 inhibitors (CDK4/6i) in the pre-clinical and clinical spaces are largely concerned with gaining a deeper understanding of how these drugs delay tumor growth, and how to prevent cancer cell resistance. By coordinating a first-in-kind phase II clinical trial of the CDK4/6i abemaciclib for patients with progressive dedifferentiated liposarcoma (DDLS) with...

    Subject
    Cellular Senescence
    Cyclin-Dependent Kinase Inhibitor Proteins
    Liposarcoma
    Liposarcoma/drug therapy
    RNA-Seq
    Access Rights
    Free to All
  • Validation of dedifferentiated liposarcoma (DDLS) cell lines with the original tumors via copy number alteration analysis [sequencing]

    Authors
    Okada, Tomoyo
    Gularte-Mérida, Rodrigo
    Shen, Yawei
    Singer, Samuel
    Description

    Summary from GEO: "We validated patient's tumor-derived cell lines of liposarcoma by analysing copy number alterations using aCGH or WGS and comparing with the original tumor tissues." Overall design from GEO: "Examination of copy number alterations for 2 cell lines, one of the original tumor, one PDX-tumor and its original tumor."

    Subject
    Cell Line, Tumor
    DNA Copy Number Variations
    Liposarcoma
    Access Rights
    Free to All
  • Validation of dedifferentiated liposarcoma (DDLS) cell lines with the original tumors via copy number alteration analysis [array]

    Authors
    Okada, Tomoyo
    Gularte-Mérida, Rodrigo
    Shen, Yawei
    Singer, Samuel
    Description

    Summary from GEO: "We validated patient's tumor-derived cell lines of liposarcoma by analysing copy number alterations using aCGH or WGS and comparing with the original tumor tissues." Overall design from GEO: "Examination of copy number alterations for 2 cell lines, one of the original tumor, one PDX-tumor and its original tumor."

    Subject
    Cell Line, Tumor
    DNA Copy Number Variations
    Liposarcoma
    Access Rights
    Free to All