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Results Found: 32
  • Effect of Ro 08-2750 treatment on gene expression of human leukemia cell lines MOLM13 and K562

    Authors
    Minuesa, Gerard Dinares
    Passarelli, Maria C.
    Fairchild, Lauren E.
    Leslie, Christina
    1 more author(s)...
    Description

    Summary from the GEO: "RNA-sequencing on human leukemia cell lines MOLM13 (AML, MLL-AF9+) and K562 (CML-BC, BCR-ABL+) after Ro 08-2750 treatment (20 uM, 4hours). Cells were cultured at 0.5M/mL and treated with the small-molecule Ro 08-2750 for 4hours at 20 uM." The dataset is associated with the MUSASHI (MSI) family of RNA binding proteins (MSI1 and MSI2). According to the associated article, the...

    Subject
    Leukemia, Myeloid, Acute
    RNA-Binding Proteins
    Access Rights
    Free to All
  • RNA-recognition motif 1 of human MSI2

    Authors
    Goldgur, Yehuda
    Kharas, Michael G.
    Minuesa, Gerard Dinares
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the RNA-recognition motif 1 of human MSI2. The main summary display for this entry includes an experimental data snapshot, protein source, macromolecules and small molecules included in the deposit, and version history and funding identification....

    Subject
    Protein Structure, Quaternary
    Protein Structure, Secondary
    Protein Structure, Tertiary
    RNA-Binding Proteins
    Access Rights
    Free to All
  • Cryo-EM structure of Csm-crRNA binary complex in type III-A CRISPR-Cas system

    Authors
    Jia, Ning
    Wang, Chongyuan
    Eng, Edward T.
    Patel, Dinshaw J.
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the Cryo-EM structure of Csm-crRNA binary complex in type III-A CRISPR-Cas system. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit,...

    Subject
    CRISPR-Cas Systems
    RNA-Binding Proteins
    Access Rights
    Free to All
  • Cryo-EM structure of ternary Csm-crRNA-target RNA with anti-tag sequence complex in type III-A CRISPR-Cas system

    Authors
    Jia, Ning
    Wang, Chongyuan
    Eng, Edward T.
    Patel, Dinshaw J.
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the Cryo-EM structure of ternary Csm-crRNA-target RNA with anti-tag sequence complex in type III-A CRISPR-Cas system. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small...

    Subject
    CRISPR-Cas Systems
    RNA-Binding Proteins
    Access Rights
    Free to All
  • Cryo-EM structure of larger Csm-crRNA-target RNA ternary complex in type III-A CRISPR-Cas system

    Authors
    Jia, Ning
    Wang, Chongyuan
    Eng, Edward T.
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the Cryo-EM structure of larger Csm-crRNA-target RNA ternary complex in type III-A CRISPR-Cas system. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included...

    Subject
    CRISPR-Cas Systems
    RNA-Binding Proteins
    Access Rights
    Free to All
  • Cryo-EM structure of Csm-crRNA-target RNA ternary complex in type III-A CRISPR-Cas system

    Authors
    Jia, Ning
    Wang, Chongyuan
    Eng, Edward T.
    Patel, Dinshaw J.
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the Cryo-EM structure of Csm-crRNA-target RNA ternary complex in type III-A CRISPR-Cas system. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in...

    Subject
    CRISPR-Cas Systems
    RNA-Binding Proteins
    Access Rights
    Free to All
  • Crystal structure of Csm1-Csm4 subcomplex in the type III-A CRISPR-Csm interference complex

    Authors
    Jia, Ning
    Patel, Dinshaw J.
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the Crystal structure of Csm1-Csm4 subcomplex in the type III-A CRISPR-Csm interference complex. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in...

    Subject
    CRISPR-Cas Systems
    RNA-Binding Proteins
    Access Rights
    Free to All
  • HyperTRIBE uncovers MSI2 increased RNA binding activity and differential regulation in leukemic stem cells [LSK cells]

    Authors
    Nguyen, Diu Thi Thanh
    Lu, Yuheng
    Choo, Zi-Ning
    Chu, Karen
    6 more author(s)...
    Description

    Summary from the GEO: " Understanding RBPs’ molecular functions as well as their cell-type specific activity requires identification of RBPs’ direct mRNA targets. However, efforts to identify RNA targets of RNA binding proteins in stem cells have been hindered by limited cell numbers. Here we adapted the HyperTRIBE method using an RBP fused to a Drosophila RNA editing enzyme (ADAR) to allow for global...

    Subject
    Leukemia
    RNA-Binding Proteins
    Access Rights
    Free to All
  • HyperTRIBE uncovers MSI2 increased RNA binding activity and differential regulation in leukemic stem cells [LSC and LSK]

    Authors
    Nguyen, Diu Thi Thanh
    Lu, Yuheng
    Choo, Zi-Ning
    Chu, Karen
    6 more author(s)...
    Description

    Summary from the GEO: "Understanding RBPs’ molecular functions as well as their cell-type specific activity requires identification of RBPs’ direct mRNA targets. However, efforts to identify RNA targets of RNA binding proteins in stem cells have been hindered by limited cell numbers. Here we adapted the HyperTRIBE method using an RBP fused to a Drosophila RNA editing enzyme (ADAR) to allow for global...

    Subject
    Leukemia
    RNA-Binding Proteins
    Access Rights
    Free to All
  • HyperTRIBE uncovers MSI2 increased RNA binding activity and differential regulation in leukemic stem cells [MOLM-13]

    Authors
    Nguyen, Diu Thi Thanh
    Lu, Yuheng
    Choo, Zi-Ning
    Chu, Karen
    6 more author(s)...
    Description

    Summary from the GEO: "Understanding RBPs’ molecular functions as well as their cell-type specific activity requires identification of RBPs’ direct mRNA targets. However, efforts to identify RNA targets of RNA binding proteins in stem cells have been hindered by limited cell numbers. Here we adapt the HyperTRIBE method using an RBP fused to a Drosophila RNA editing enzyme (ADAR) to allow for global...

    Subject
    Leukemia
    RNA-Binding Proteins
    Access Rights
    Free to All