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MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
- Authors
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Wei, QiaozhiFrenette, Paul S.
- Description
Summary from the GEO: "Haematopoietic stem cells (HSCs) tightly regulate their quiescence, proliferation, and differentiation to generate blood cells during the entire lifetime. The mechanisms by which these critical activities are balanced are still unclear. Here, we report that Macrophage-Erythroblast Attacher (MAEA, also known as EMP), a receptor thus far only identified in erythroblastic island1,...
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Cell Adhesion MoleculesCytoskeletal ProteinsGene Expression ProfilingHematopoiesisHematopoietic Stem CellsLeukemia, Myeloid, AcuteLymphokinesUbiquitin-Protein Ligases
- Access Rights
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Free to All
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RNA-seq for UBR5-regulated genes in tumor associated macrophages
- Authors
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Song, MeiZhang, Tuo
- Description
Summary from the GEO: "RNA-seq analysis of peritoneal macrophages derived from non-tumor bearing, WT ID8 tumor-bearing, and Ubr5 KO ID8 tumor bearing C57BL/6 mice." From the publication abstract: "Immunosuppressive tumor microenvironment (TME) and ascites-derived spheroids in ovarian cancer (OC) facilitate tumor growth and progression, and also pose major obstacles for cancer therapy. The molecular...
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Macrophages, PeritonealOvarian NeoplasmsUbiquitin-Protein Ligases
- Access Rights
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Free to All
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mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase: MassIVE MSV000095724
- Authors
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Ordureau, Alban Simon Georges
- Description
Description from MassIVE: "Supporting MS data for paper (DOI:10.1016/j.celrep.2024.115179) by Pham, B. et al., titled "mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase". Related to Table S1 - HEK293 - degradomics (HA-2-165 | Unimod:35; 2016; 4 | 126 - Neg Ctrl (WT cells -AHA); 127n - MAEA-WT - UT_0h replicate 1; 127c - MAEA-WT - UT_0h replicate...
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Mass spectrometryPyrimidinesTOR Serine-Threonine KinasesUbiquitin-Protein Ligases
- Access Rights
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Free to All
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UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER: MassIVE MSV000093510
- Authors
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Ordureau, Alban Simon GeorgesPaulo, Joao A.
- Description
Description from MassIVE: "Supporting MS data for paper (doi: 10.1038/s41586-024-07073-0) by DaRosa P.A., Penchev I. et al., titled "UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER". Index of MS supporting files uploaded: - Related to Fig. 1a and Extended Data Fig. 1a (AO3435-AO3440: TMT proteomics (Unimod: 35; 737; 4)). - Related to Fig. 1b, c (see MSV000093721)."
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Mass spectrometryRibosome SubunitsUbiquitin-Protein Ligases
- Access Rights
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Free to All
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UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER: MassIVE MSV000093721
- Authors
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Ordureau, Alban Simon Georges
- Description
Description from MassIVE: "Supporting MS data for paper (doi: 10.1038/s41586-024-07073-0) by DaRosa P.A., Penchev I. et al., titled "UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER". Index of MS supporting files uploaded: Related to Related to Fig. 1b, c (xb01004(UFM1), xb01005(SBP-UFM1): LFQ IP-MS (Unimod: 35; 4))."
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Mass spectrometryRibosome SubunitsUbiquitin-Protein Ligases
- Access Rights
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Free to All
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mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase. Pham et al.
- Authors
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An, Heeseon
- Description
Description from Mendeley data: "Raw data file for metabolomics experiment in Table S2."
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MetabolomicsPyrimidinesTOR Serine-Threonine KinasesUbiquitin-Protein Ligases
- Access Rights
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Free to All