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Results Found: 17
  • Bladder Cancer (MSKCC, Nat Genet 2016): Whole exome and targeted sequencing of 34 plasmacytoid-variant (signet ring cell) tumors of the bladder

    Authors
    Al-Ahmadie, Hikmat
    Iyer, Gopakumar Vasudeva
    Lee, Byron Hing Lung
    Scott, Sasinya Neka
    25 more author(s)...
    Description

    Whole-exome and targeted sequencing of plasmacytoid bladder cancer, an aggressive histologic variant with a high risk of disease-specific mortality. This dataset contains summary data visualizations and sequencing data of 34 plasmacytoid-variant (signet ring cell) tumors of the bladder from 31 patients. Clinical data includes detailed cancer type, mutation count, information about mutated genes, patient...

    Subject
    DNA Mutational Analysis
    Plasmacytoma/genetics
    Urinary Bladder Neoplasms
    Access Rights
    Free to All
  • Whole Exome Sequencing of Six Signet Ring/Plasmacytoid Variant Bladder Tumors

    Authors
    Solit, David
    Description

    In this study, six plasmacytoid bladder cancers were analyzed by whole exome sequencing. The results show loss of the CDH1 gene in every sample and correlate with E-cadherin loss of expression by immunohistochemistry. A separate validation cohort of plasmacytoid samples showed loss of E-cadherin expression by CDH1 mutation or promoter hypermethylation. The data includes information about the study,...

    Subject
    DNA Mutational Analysis
    Mutation
    Plasmacytoma/genetics
    Urinary Bladder Neoplasms
    Access Rights
    Application Required
  • A Molecular Taxonomy of Urothelial Carcinoma

    Authors
    Sjödahl, Gottfrid
    Lauss, Martin
    Lindgren, David
    Höglund, Mattias
    Description

    Summary from the GEO: " Even though urothelial cancer (UC) is the fourth common tumor type among males, progress in treatment development has been deficient. Pathological assessment provides the urologists with only a broad classification, complicated by frequent disagreement among pathologist and the co-existence of different grading systems. Consequently, there is a great need for an objective,...

    Subject
    Gene Expression Profiling
    Urinary Bladder Neoplasms
    Access Rights
    Free to All
  • Bladder Urothelial Carcinoma (TCGA, PanCancer Atlas): Bladder Urothelial Carcinoma TCGA PanCancer data.

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of 411 bladder urothelial carcinomas from 411 patients. The data was gathered as part of the PanCancer Atlas initiative, which aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset. The clinical data includes mutation count, information...

    Subject
    DNA Mutational Analysis
    Urinary Bladder Neoplasms
    Access Rights
    Free to All
  • Bladder Cancer (TCGA, Cell 2017): Comprehensive analysis of muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms.

    Authors
    Robertson, A. Gordon
    Kim, Jaegil
    Al-Ahmadie, Hikmat
    Bellmunt, Joaquim
    39 more author(s)...
    Description

    This dataset contains summary data visualizations and clinical data for a list of oncogenic and likely oncogenic alterations in 413 samples in tumors of the bladder from 412 patients, gathered as part of a comprehensive molecular characterization of muscle-invasive bladder cancer. Clinical data includes mutation count, information about mutated genes, patient demographics, and American Joint Committee...

    Subject
    DNA Mutational Analysis
    Urinary Bladder Neoplasms
    Access Rights
    Free to All
  • RNA sequencing data for 30 bladder cancer cell lines

    Authors
    Lee, I-Ling
    McConkey, David J.
    Su, Xiaoping
    Choi, Woonyoung
    Description

    Summary from the GEO: "RNA-sequencing of a panel of urothelial cancer cells. The goal of the study is to examine the genome-wide expression profile in each of the 30 urothelial cancer cells tested in our laboratory." "Overall design: Each of the 30 cell lines was DNA fingerprinted to confirm its real identity. Total RNA was obtained from each cell line and subjected to Illumina RNA sequencing."...

    Subject
    Gene Expression Profiling
    Urinary Bladder Neoplasms
    Access Rights
    Free to All
  • MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017): Targeted sequencing of 10,000 clinical cases using the MSK-IMPACT assay

    Description

    This dataset contains summary data visualizations and clinical data from the targeted sequencing of 10,000 clinical cases using the MSK-IMPACT assay. The clinical data includes mutation count, information about mutated genes, tumor mutational burden calculations, tissue site from which the sample was derived, tumor purity among other relevant data points. The data set also includes copy-number segment...

    Subject
    Adenocarcinoma
    Adenocarcinoma of Lung
    Adenocarcinoma, Mucinous
    Breast Neoplasms
    Carcinoma, Ductal, Breast
    Carcinoma, Hepatocellular
    Carcinoma, Lobular
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Renal Cell
    Carcinoma, Squamous Cell
    Carcinosarcoma
    Cholangiocarcinoma
    Colonic Neoplasms
    Colorectal Neoplasms
    Cystadenocarcinoma, Serous
    DNA Mutational Analysis
    Gallbladder Neoplasms
    Glioblastoma
    Liposarcoma
    Lung Neoplasms
    Lymphoma, Follicular
    Melanoma
    Mesothelioma
    Neoplasms, Squamous Cell
    Neurofibroma
    Oligodendroglioma
    Osteosarcoma
    Ovarian Neoplasms
    Pancreatic Neoplasms
    Prostatic Neoplasms
    Rectal Neoplasms
    Sarcoma
    Sarcoma, Synovial
    Squamous Cell Carcinoma of Head and Neck
    Stomach Neoplasms
    Thyroid Cancer, Papillary
    Urinary Bladder Neoplasms
    Uterine Neoplasms
    Uveal Neoplasms
    Access Rights
    Free to All
  • Upper Tract Urothelial Cancer (MSK, Eur Urol 2015): Next-generation sequencing (MSK-IMPACT) on all protein-coding exons of 300 cancer associated genes of 85 Upper Tract Urothelial Carcinoma tumor samples and paired normals.

    Description

    This dataset contains summary data visualizations and clinical data from a broad of 85 samples of upper tract urothelial carcinoma tumors from 83 patients. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes mutation count, information about mutated genes, patient demographics, disease status, Adjuvant Chemotherapy, American Joint Committee on Cancer...

    Subject
    DNA Mutational Analysis
    Kidney Neoplasms
    Ureteral Neoplasms
    Urinary Bladder Neoplasms
    Access Rights
    Free to All
  • Upper Tract Urothelial Carcinoma PDX (MSK, 2019): MSK-IMPACT sequencing of 34 upper tract urothelial patients and the matching PDX or PDC generated from 17 patient tumors.

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of upper tract unothelial carcinoma tumors. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, patient demographics, American Joint Committee...

    Subject
    DNA Mutational Analysis
    Kidney Neoplasms
    Ureteral Neoplasms
    Urinary Bladder Neoplasms
    Access Rights
    Free to All
  • SUMMIT - Neratinib Basket Study (Multi-Institute, Nature 2018): MSK-IMPACT sequencing of 86 patients with HER2- and HER3-mutant cancers

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of HER2- and HER3-mutant tumors. The data was generated utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, Amplification Status, Best objective response rate, Bubble...

    Subject
    Breast Neoplasms
    Carcinoma, Hepatocellular
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Renal Cell
    Colorectal Neoplasms
    DNA Mutational Analysis
    Endometrial Neoplasms
    Esophageal Neoplasms
    Genes, erbB
    Genes, erbB-2
    Melanoma
    Ovarian Neoplasms
    Pancreatic Neoplasms
    Salivary Gland Neoplasms
    Sarcoma
    Skin Neoplasms
    Urinary Bladder Neoplasms
    Uterine Cervical Neoplasms
    Access Rights
    Free to All