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Cancer Therapy and Clonal Hematopoiesis (MSK, Clin Cancer Res 2022)
- Description
Clonal hematopoiesis mutations identified in blood samples from patients whose tumor-blood pairs were analyzed using MSK-IMPACT. The clinical data includes mutation count, information about mutated genes, patient demographics, and information about treatment. The data set also includes charts visualizing data summaries and customizable plotting tool.
- Subject
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Clinical TrialDrug TherapyHematopoiesisMutation/genetics
- Access Rights
- Free to All
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Genome Sequencing Reveals That RAD50 Hypomorphism Results in Enhanced Sensitivity to Checkpoint Kinase Inhibition Combined with Chemotherapy
- Authors
- Taylor, Barry StephenSolit, DavidPetrini, John
- Description
From the dbGaP study description: "Outlier analyses represent a versatile method to identify predictive biomarkers of response to both targeted agents and chemotherapy. We performed whole genome sequencing (WGS) of tumor and germline blood from a patient with metastatic small cell carcinoma of the ureter who experienced a durable complete response to a combination of irinotecan plus AZD7762, a checkpoint...
- Subject
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Carcinoma, Small CellDrug TherapyGenomicsImmune Checkpoint InhibitorsProtein Kinase InhibitorsWhole Genome Sequencing
- Access Rights
- Application Required
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Whole Genome and Exon Capture Sequencing of Bladder Cancers
- Authors
- Solit, DavidTaylor, Barry Stephen
- Description
From the dbGaP study description: "One primary bladder cancer and paired peripheral blood sample were subjected to whole genome sequencing on an Illumina HiSeq 2000 platform. This technology was utilized to investigate the genetic basis of a durable remission of metastatic bladder cancer in a patient treated with everolimus, a drug that inhibits the mTOR (mammalian target of rapamycin) signaling...
- Subject
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Drug TherapyNeoplasm MetastasisTOR Serine-Threonine KinasesUrinary Bladder NeoplasmsWhole Genome Sequencing
- Access Rights
- Application Required
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Bladder Chemotherapy Responders
- Authors
- Garraway, Levi A.Rosenberg, Jonathan Eric
- Description
Description from dbGaP: "Cisplatin-based chemotherapy is the standard of care for patients with muscle invasive urothelial carcinoma. Pathologic downstaging to pT0/pTis after neoadjuvant cisplatin-based chemotherapy is associated with improved survival, and some patients with metastatic disease achieve complete responses to these therapies. However, the molecular determinants of cisplatin response...
- Subject
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CisplatinDrug TherapyExome SequencingNeoplasm MetastasisUrinary Bladder Neoplasms
- Access Rights
- Application Required
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Mutational Landscape Determines Sensitivity to PD-1 Blockade in Non-Small Cell Lung Cancer
- Authors
- Chan, Timothy A.Hellmann, Matthew D.
- Description
From the dbGaP study description: "Patients with non-small cell lung cancer were treated with pembrolizumab. Their tumors and matched normal blood were sequenced."
- Subject
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Carcinoma, Non-Small-Cell LungDrug TherapyImmune Checkpoint InhibitorsMutation
- Access Rights
- Application Required
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Framework for Measuring Cancer Treatment Cost and Quality
- Authors
- Mitchell, Aaron Philip
- Description
Description from Zenodo: "The Framework contains clinical evidence scores and anticipated treatment costs of all recommended medical treatment options for all major cancer types. The sets of recommended treatments and clinical evidence scores are based on recommendations from the National Comprehensive Cancer Network (NCCN). Treatment costs use Medicare reimbursement rates. Data are updated every...
- Subject
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Antineoplastic ProtocolsComparative Effectiveness ResearchDrug TherapyHealth Care CostsMeta-Analysis as Topic
- Access Rights
- Free to All
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Multi-region sequencing of tumor samples from PDAC patients
- Description
Description from EGA: "This study includes 542 of multi-region sampled whole exome sequencing data from 83 pancreatic cancer patients in 6 individual experiments : Kras wildtype, local recurrence, treatment-naive (MetomeV2), radiotherapy plus chemotherapy (Radome), chemotherapy-only group (Treatome) and Proj_B-100-478." Dataset is also accessioned as a study, associated with publication "The Evolutionary...
- Subject
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ChemoradiotherapyDrug TherapyExome SequencingGenes, rasNeoplasm Recurrence, LocalPancreatic NeoplasmsRadiotherapy
- Access Rights
- Author approval required