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Results Found: 43
  • Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture

    Authors
    Yusufova, Nevin
    Teater, Matt
    Cesarman, Ethel
    Melnick, Ari M.
    1 more author(s)...
    Description

    Summary from the GEO: "Linker histone H1 proteins bind to nucleosomes and cause chromatin compaction, although little is known about their biological functions. Histone H1 (HIST1H1B-E) mutations are highly recurrent in B-cell lymphomas and are present in solid tumors, but their cancer relevance and mechanism are unknown. Here we report that lymphoma-associated H1 alleles are genetic driver mutations...

    Subject
    B-Lymphocytes
    Gene Silencing
    Genes, Tumor Suppressor
    Histones
    Lymphoma
    Sequence Analysis
    Access Rights
    Free to All
  • A multivalent signal-transducing model for the DNMT1-mediated maintenance DNA methylation

    Authors
    Wang, Gang G.
    Grimm, Sara A.
    Description

    Summary from the GEO: "Heterochromatin-specific histone modifications frequently coexist with mammalian DNA methylation to orchestrate a repressive chromatin state. However, it remains elusive how these epigenetic modifications crosstalk. Here, we report that the first bromoadjacent homology (BAH1) domain and the replication foci targeting sequence (RFTS) of maintenance DNA methyltransferase DNMT1...

    Subject
    DNA (Cytosine-5-)-Methyltransferase 1
    DNA Methylation
    Heterochromatin
    Histone Code
    Histones
    Access Rights
    Free to All
  • Crystal structure of bovine DNMT1 BAH1 domain in complex with H4K20me2

    Authors
    Ren, Wendan
    Song, Jikui
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data used for modeling the crystal structure of bovine DNMT1 BAH1 domain in complex with H4K20me2. The main summary display for this entry includes information on the experimental data, validation, macromolecules, small molecules, version history and funding identification. Data...

    Subject
    DNA (Cytosine-5-)-Methyltransferase 1
    Histones
    Methyltransferases
    Repressor Proteins
    Access Rights
    Free to All
  • Crystal structure of bovine DNMT1 BAH1 domain in complex with H4K20me3

    Authors
    Ren, Wendan
    Song, Jikui
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes x-ray diffraction data used for modeling the crystal structure of bovine DNMT1 BAH1 domain in complex with H4K20me3. The main summary display for this entry includes information on the experimental data, validation, macromolecules, small molecules, version history and funding identification. Data...

    Subject
    DNA (Cytosine-5-)-Methyltransferase 1
    Histones
    Methyltransferases
    Repressor Proteins
    Access Rights
    Free to All
  • Histone H3 threonine 11 phosphorylation is catalyzed directly by the meiosis-specific kinase Mek1 and provides a molecular readout of Mek1 activity in vivo

    Authors
    Kniewel, Ryan
    Murakami, Hajime
    Liu, Yan
    Ito, Masaru
    3 more author(s)...
    Description

    Summary from the GEO: "Saccharomyces cerevisiae Mek1 is a CHK2/Rad53-family kinase that regulates meiotic recombination and progression upon its activation in response to DNA double-strand breaks (DSBs). The full catalog of direct Mek1 phosphorylation targets remains unknown. Here, we show that phosphorylation of histone H3 on threonine 11 (H3 T11ph) is induced by meiotic DSBs in S. cerevisiae and...

    Subject
    Checkpoint Kinase 2
    Chromatin Immunoprecipitation Sequencing
    Histones
    Phosphorylation
    Protein-Serine-Threonine Kinases
    Access Rights
    Free to All
  • Whole genome ChIP-seq of histone H3 threonine 11 phosphorylation in Saccharomyces cerevisiae

    Authors
    Murakami, Hajime
    Kniewel, Ryan
    Keeney, Scott
    Description

    Summary from the GEO: "We used ChIP-seq to determine the whole-genome enrichment of histone H3 threonine 11 phosphorylation (H3 T11ph) during Saccharomyces cerevisiae meiosis. S. cerevisiae SK1 cells were synchronized for meiotic entry and 3 and 4 hour meiotic samples were obtained. As H3 T11ph is dependent on the formation of meiotic double strand breaks (DSBs), a negative control ChIP-seq sample...

    Subject
    Chromatin Immunoprecipitation Sequencing
    Histones
    Phosphorylation
    Protein-Serine-Threonine Kinases
    Access Rights
    Free to All
  • Proteomics Data for "DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network"

    Authors
    Hendriks, Ivo
    Nielsen, Michael L.
    Description

    Description from PRIDE: "From biosynthesis to assembly into nucleosomes, histones are handed through a cascade of histone chaperones, which shield histones from non-specific interactions. Whether mechanisms exist to safeguard the histone fold during histone chaperone handover events or to release trapped intermediates is unclear. Using structure-guided and functional proteomics, we identify and characterize...

    Subject
    Histone Chaperones
    Histones
    HSP40 Heat-Shock Proteins
    HSP70 Heat-Shock Proteins
    Minichromosome Maintenance Complex Component 2
    Access Rights
    Free to All
  • DNAJC9 Integrates Heat Shock Molecular Chaperones into the Histone Chaperone Network

    Authors
    Hammond, Colin M.
    Reverón-Gómez, Nazaret
    Groth, Anja
    Description

    Summary from the GEO: "From biosynthesis to assembly into nucleosomes, histones are handed through a cascade of histone chaperones, which shield histones from non-specific interactions. Whether mechanisms exist to safeguard the histone fold during histone chaperone handover events or to release trapped intermediates is unclear. Using structure-guided and functional proteomics, we identify and characterize...

    Subject
    Histone Chaperones
    Histones
    HSP40 Heat-Shock Proteins
    HSP70 Heat-Shock Proteins
    Minichromosome Maintenance Complex Component 2
    Access Rights
    Free to All
  • Crystal structure of DNAJC9 HBD helix2 in complex with H3.3-H4 dimer and MCM2 HBD

    Authors
    Bao, Hongyu
    Huang, Hongda
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes electron microscopy data identifying the crystal structure of DNAJC9 HBD helix2 in complex with H3.3-H4 dimer and MCM2 HBD. The main summary display for this entry includes information on the experimental method, validation, macromolecules and small molecules included in the deposit, as well as...

    Subject
    Histone Chaperones
    Histones
    HSP40 Heat-Shock Proteins
    Minichromosome Maintenance Complex Component 2
    Access Rights
    Free to All
  • Crystal structure of DNAJC9 HBD in complex with H3.3-H4 dimer and MCM2 HBD

    Authors
    Bao, Hongyu
    Huang, Hongda
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes electron microscopy data identifying the crystal structure of DNAJC9 HBD in complex with H3.3-H4 dimer and MCM2 HBD. The main summary display for this entry includes information on the experimental method, validation, macromolecules and small molecules included in the deposit, as well as version...

    Subject
    Histone Chaperones
    Histones
    HSP40 Heat-Shock Proteins
    Minichromosome Maintenance Complex Component 2
    Access Rights
    Free to All