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Effect of loss of Jmjd1c on H3K9me2 level across the genome
- Authors
- Zhu, NanRahnamay, Noushin F.Sinha, Amit U.Koche, Richard Patrick1 more author(s)...
- Description
Summary from GEO: "Analysis of H3K9me2 level in MLL-AF9 leukemia cells upon deletion of Jmjd1c. Jmjd1c has been shown to be a H3K9me1/2 demethylase and these results provide insight into its role in MLL-Af9 leukemia" Overall design from GEO: "We used primary Jmjd1c f/f MLL-AF9-GFP leukemia cells and delivered Cre-Tomato retroviral infection. Cells infected with virus made from empty vector was...
- Subject
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Chromatin Immunoprecipitation SequencingHistonesJumonji Domain-Containing Histone DemethylasesLeukemia, Myeloid, AcuteSingle-Cell Analysis
- Access Rights
- Free to All
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Effect of loss of Jmjd1c on MLL-AF9 leukemia
- Authors
- Zhu, NanRahnamay, Noushin F.Sinha, Amit U.Koche, Richard Patrick1 more author(s)...
- Description
Summary from GEO: "Analysis of gene expression profile of MLL-AF9 leukemia cells 6 days after loss of Jmjd1c. Loss of Jmjd1c induces differentiation and apoptosis in MLL-AF9 leukemia cells. These results provide insight into the role of Jmjd1c in MLL leukemia." Overall design from GEO: "We used primary Jmjd1c f/f MLL-AF9-GFP leukemia cells from four leukemic mice and delivered Cre-Tomato by retroviral...
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Gene ExpressionJumonji Domain-Containing Histone DemethylasesLeukemia, Myeloid, AcuteRNA-SeqViral Infections
- Access Rights
- Free to All
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Effect of loss of Jmjd1c on normal hematopoiesis
- Authors
- Zhu, NanRahnamay, Noushin F.Sinha, Amit U.Koche, Richard Patrick1 more author(s)...
- Description
Summary from GEO: "Analysis of gene expression profile of LSK (Lin-Sca-1+ c-Kit+) isolated from Jmjd1c f/f Vav1Cre or Vav1Cre controls. Loss of Jmjd1c minimally affected HSC in homeostatsis while impiars HSC function in response to stree such as transplantation and 5-Fu treatment. These results provide insight into the role of Jmjd1c in normal hematopoiesis." Overall design from GEO: "LSK cells...
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Gene ExpressionHematopoiesisJumonji Domain-Containing Histone DemethylasesLeukemia, Myeloid, AcuteRNA-Seq
- Access Rights
- Free to All