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  • Effect of loss of Jmjd1c on H3K9me2 level across the genome

    Authors
    Zhu, Nan
    Rahnamay, Noushin F.
    Sinha, Amit U.
    Koche, Richard Patrick
    1 more author(s)...
    Description

    Summary from GEO: "Analysis of H3K9me2 level in MLL-AF9 leukemia cells upon deletion of Jmjd1c. Jmjd1c has been shown to be a H3K9me1/2 demethylase and these results provide insight into its role in MLL-Af9 leukemia" Overall design from GEO: "We used primary Jmjd1c f/f MLL-AF9-GFP leukemia cells and delivered Cre-Tomato retroviral infection. Cells infected with virus made from empty vector was...

    Subject
    Chromatin Immunoprecipitation Sequencing
    Histones
    Jumonji Domain-Containing Histone Demethylases
    Leukemia, Myeloid, Acute
    Single-Cell Analysis
    Access Rights
    Free to All
  • Effect of loss of Jmjd1c on MLL-AF9 leukemia

    Authors
    Zhu, Nan
    Rahnamay, Noushin F.
    Sinha, Amit U.
    Koche, Richard Patrick
    1 more author(s)...
    Description

    Summary from GEO: "Analysis of gene expression profile of MLL-AF9 leukemia cells 6 days after loss of Jmjd1c. Loss of Jmjd1c induces differentiation and apoptosis in MLL-AF9 leukemia cells. These results provide insight into the role of Jmjd1c in MLL leukemia." Overall design from GEO: "We used primary Jmjd1c f/f MLL-AF9-GFP leukemia cells from four leukemic mice and delivered Cre-Tomato by retroviral...

    Subject
    Gene Expression
    Jumonji Domain-Containing Histone Demethylases
    Leukemia, Myeloid, Acute
    RNA-Seq
    Viral Infections
    Access Rights
    Free to All
  • Effect of loss of Jmjd1c on normal hematopoiesis

    Authors
    Zhu, Nan
    Rahnamay, Noushin F.
    Sinha, Amit U.
    Koche, Richard Patrick
    1 more author(s)...
    Description

    Summary from GEO: "Analysis of gene expression profile of LSK (Lin-Sca-1+ c-Kit+) isolated from Jmjd1c f/f Vav1Cre or Vav1Cre controls. Loss of Jmjd1c minimally affected HSC in homeostatsis while impiars HSC function in response to stree such as transplantation and 5-Fu treatment. These results provide insight into the role of Jmjd1c in normal hematopoiesis." Overall design from GEO: "LSK cells...

    Subject
    Gene Expression
    Hematopoiesis
    Jumonji Domain-Containing Histone Demethylases
    Leukemia, Myeloid, Acute
    RNA-Seq
    Access Rights
    Free to All