RNA-seq performed on NK cells harvested during in-vivo infection. Natural killer (NK) cells are innate lymphocytes that have been recently appreciated to display features of adaptive immunity in response to viral infection. Biallelic mutations in the IRF8 gene have been reported to cause familial NK cell deficiency and susceptibility to severe viral infection in humans; however, the precise role...

Natural killer (NK) cells are innate lymphocytes that possess features of adaptive immunity such as clonal expansion and generation of long-lived memory. Here we look at transcriptional profiles of NK cells throughout several time points during MCMV infection, ex-vivo cytokine stimulation, and/or deficiency of key transcription factors such as STAT4, STAT1, and Runx1. In addition, we profile parallel...

Summary from GEO: "Analysis of gene expression profile of MLL-AF9 leukemia cells 6 days after loss of Jmjd1c. Loss of Jmjd1c induces differentiation and apoptosis in MLL-AF9 leukemia cells. These results provide insight into the role of Jmjd1c in MLL leukemia." Overall design from GEO: "We used primary Jmjd1c f/f MLL-AF9-GFP leukemia cells from four leukemic mice and delivered Cre-Tomato by retroviral...

Description from BioProject: "Humans differ in their susceptibility to infectious disease, partly due to variation in the immune response following infection. We used single-cell RNA-sequencing to quantify variation in the response to influenza infection in peripheral blood mononuclear cells from European- and African-ancestry males. Genetic ancestry effects are common but highly cell type-specific....

Description from Zenodo: "Input files and scripts to run the main analyses for influenza A virus (IAV) response variation project. The pipeline is published on GitHub as "IAV_population-variation" (https://github.com/herandolph/IAV_population-variation). " Description from GitHub: "code necessary to reproduce the main analyses published in: Genetic ancestry effects on the response to viral infection...