Single-cell genome sequencing of breast cancer. Raw sequence reads from 2,040 SRA experiments based on 18 BioSamples. This data was generated for the study "Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing." Published in eLife.

BioProject description: "Genome sequencing of Listeria seeligeri LS46 and LS59". The whole genome sequencing of these listeriaphage enabled researchers to discover that AcrVIA1, an anti-CRISPR protein, interacts with the guide-exposed face of Cas13a, a (crRNA)-guided nuclease, preventing access to the target RNA and the conformational changes required for nuclease activation. A single dose of AcrVIA1...

Summary from GEO: "DNMT3A mutations are observed in myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). Here we investigated the impact of conditional hematopoietic Dnmt3a loss on disease phenotype in primary mice. Dnmt3a ablation led to a lethal, fully penetrant myeloproliferative neoplasm with myelodysplasia (MDS/MPN)...

The Multiple Myeloma Research Foundation (MMRF) runs a multi-site longitudinal clinical registry study of patients newly diagnosed with MM. This project is called CoMMpass, and collects both clinical and genomic information periodically. Researchers used interim analysis 19 (IA19) for their conclusions in "Gene interaction network analysis in multiple myeloma detects complex immune dysregulation...

Whole genome sequencing of 37 medulloblastoma tumors and their matched normals from the Pediatric Cancer Genome Project (PCGP), a joint project by St. Jude Children's Research Hospital and Washington University. The clinical data includes patient demographics, information about survival status, tumor cellularity dominant pathology reviews, and mutation counts. The data set also includes charts visualizing...

Whole genome or whole exome sequencing of 491 previously untreated Medulloblastoma tumor/normal pairs. The clinical data consists of 491 samples from 491 patients, and includes mutation count, structural variants, patient demographics, and tumor subtypes. The data set also includes charts visualizing data summaries and a customizable plotting tool.

Whole-genome sequencing of 46 recurrent medulloblastoma samples from 46 patients. The clinical data includes patient demographics, structural variants, mutation counts, and a KM plot. The data set also includes charts visualizing data summaries and a customizable plotting tool.

Description from EGA: "The Chronic Lymphocytic Leukemia (CLL) Genome Project aims to identify genetic alterations involved in the development and progression of the CLL, which are still unknown, with the objective of generating a comprehensive catalogue of genetic alterations in 500 independent tumours. The CLL Genome Project, as a contributing member of the International Cancer Genome Consortium...

Description from EGA: "Analysis of mutational signatures is becoming routine in cancer genomics, with implications for pathogenesis, classification, prognosis, and even treatment decisions. However, the field lacks a consensus on analysis and result interpretation. Using whole-genome sequencing of multiple myeloma (MM), chronic lymphocytic leukemia (CLL) and acute myeloid leukemia, we compare the...

Description from EGA: "A set of tumor/normal paired sequencing experiments, performed in short read WGS and 10X linked read whole genomes. BAM files aligned to hg19 are provided. Sample Alias number and Subject ID reflects patient of origin. T/N distinction discriminates between tumor and normal (peripheral blood) tissue."