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Germ Cell Tumors and Shared Leukemias: Targeted and WES sequencing of germ cell tumor and shared leukemia samples
- Description
This dataset contains the summary data visualizations and clinical data of 21 samples from 11 patients of targeted and WES sequencing of germ cell tumor and shared leukemia samples. Clinical data includes: Cancer Type, Number of Samples per Patient, Mutation Count, Fraction Genome Altered, Specimen Preservation Type, Platform and Somatic Status. The plaintext components of the dataset can be downloaded...
- Subject
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Histiocytic SarcomaKiller Cells, NaturalLeukemia, Myeloid, AcuteLeukemia, Myelomonocytic, ChronicLymphohistiocytosis, HemophagocyticLymphoma, T-CellMyelodysplastic SyndromesNeoplasms, Germ Cell and Embryonal
- Access Rights
- Free to All
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Myelodysplastic (MSKCC, 2020): Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms
- Description
This dataset contains the summary data visualizations and clinical data from 4,231 myeloid neoplasm samples from 4,231 patients. Clinical data includes: Cancer Type, Cancer Type Detailed, Mutation Count, Oncotree Code, Sequencing Type, Somatic Status, Study. The plaintext components of the dataset can be downloaded as a tar file. The clinical data can be downloaded as a tsv file.
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Acute monoblastic/monocytic leukemiaAnemia, RefractoryAnemia, Refractory, with Excess of BlastsAnemia, SideroblasticLeukemia, Erythroblastic, AcuteLeukemia, Megakaryoblastic, AcuteLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteLeukemia, Myelomonocytic, AcuteLeukemia, Myelomonocytic, ChronicMastocytosisMyelodysplastic SyndromesMyelodysplastic-Myeloproliferative DiseasesOncogene Proteins, FusionPolycythemia VeraPrimary MyelofibrosisSarcoma, MyeloidThrombocythemia, Essential
- Access Rights
- Free to All
- Local Expert
- Papaemmanuil, Elli
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(Metabolome analysis data): Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway
- Authors
- Kitamura, Toshio
- Description
Description from MassIVE: Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations drive CH remains elusive. Using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT), we examined the influence of ASXL1-MT on physiological aging in hematopoietic stem cells (HSCs). HSCs expressing ASXL1-MT display competitive...
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Clonal HematopoiesisHematopoietic Stem CellsMetabolomeMyelodysplastic Syndromes
- Access Rights
- Free to All