This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the The CRAC channel Orai in an open conformation; H206A gain-of-function mutation. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit,...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the CRAC channel Orai in an unlatched-closed conformation; K163W loss-of-function mutation. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the CRAC channel Orai in an unlatched-closed conformation. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history and...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the CRAC channel Orai in an unlatched-closed conformation; K163W loss-of-function mutation; P42212 crystal form. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules...

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the cryo-EM structure of the CRAC channel Orai in an open conformation; H206A gain-of-function mutation in complex with an antibody. The main summary display for this entry includes information on the experimental method, validation, macromolecules...

Summary from GEO: "Although the biological utilities of endogenous RNAi (endo-RNAi) have been largely elusive, recent studies reveal its critical role in the non-model fruitfly Drosophila simulans to suppress selfish genes, whose unchecked activities can severely impair spermatogenesis. In particular, hairpin RNA (hpRNA) loci generate endo-siRNAs that suppress evolutionary novel, X-linked, meiotic...

Summary from GEO: "ELAV/Hu factors are conserved RNA binding proteins that play diverse roles in mRNA processing and regulation. The founding member, Drosophila Elav, was recognized as a vital neural factor 35 years ago. Nevertheless, still little is known about its impacts on the transcriptome, and potential functional overlap with its paralogs. Building on our recent findings that neural-specific...

Summary from GEO: "The goal of this study is to perform quantitative comparison of transcriptome-wide 3'-end features of Drosophila melanogaster 1st instar larvae central neural system (L1CNS) from three genotypes: Canton-S, elav5 single mutant, and elav5/fne double mutant; Total RNAs were extracted from dissected L1CNS of Drosophila melanogaster Canton-S, elav5 single mutant, and elav5/fne double...

Summary from GEO: "The survival and reproductive success of animals depends on the ability to harmonize their external behaviors with their internal states. For example, females conduct numerous social programs that are distinctive to virgins compared to post-mated and/or pregnant individuals. In Drosophila, the fact that the post-mating switch is initiated by seminal factors implies the default...

Summary from GEO: "The knockdown of Tmod, an actin-capping protein, decreases the expression of proteasomal degradation genes and increase expression of oxidative metabolism genes. It is also critical for the correct expression of larval actin isoforms." Overall design from GEO: "Performed gene expression profiling analysis using data obtained from RNA-seq of 2 experimental groups (tmodRNAi vs...