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Results Found: 15
  • Anaplastic Oligodendroglioma and Anaplastic Oligoastrocytoma (MSKCC, Neuro Oncol 2017): Genomic characterization using next generation sequencing (NGS) in 22 Anaplastic Oligodendroglioma and Anaplastic Oligoastrocytomas.

    Authors
    Thomas, Alissa A.
    Abrey, Lauren E.
    Terziev, Robert
    Raizer, Jeffrey J.
    24 more author(s)...
    Description

    This dataset contains summary data visualizations and sequencing data of 22 anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA) tumors from 19 patients following a trial using induction temozolomide (TMZ) followed by myeloablative high-dose chemotherapy (HDC) with autologous stem-cell transplant (ASCT) as a potential strategy to defer radiotherapy. The clinical data includes mutation...

    Subject
    Brain Neoplasms
    Chemoradiotherapy
    DNA Mutational Analysis
    Oligodendroglioma
    Temozolomide
    Access Rights
    Free to All
  • Brain Lower Grade Glioma (TCGA, PanCancer Atlas): Brain Lower Grade Glioma TCGA PanCancer data.

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of 514 brain lower grade gliomas from 514 patients. The data was gathered as part of the PanCancer Atlas initiative, which aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset. The clinical data includes mutation count, information...

    Subject
    Brain Neoplasms
    DNA Mutational Analysis
    Access Rights
    Free to All
  • Organ-specific in situ transcriptomics of MDA231 cells identified by Flura-seq

    Alternate Title(s)
    Flura-seq identifies organ-specific adaptations in metastasis-initiating cells
    Authors
    Basnet, Harihar
    Tian, Lin
    Massagué, Joan
    Description

    Summary from the GEO: "Metastasis-initiating cells dynamically adapt to the distinct microenvironments of different organs, but these early adaptations are poorly understood due to the limited sensitivity of in situ transcriptomics. We developed fluorouracil-labeled RNA sequencing (Flura-seq) for in situ analysis with unprecedented sensitivity. Flura-seq utilizes cytosine deaminase (CD) to convert...

    Subject
    Brain Neoplasms
    Breast Neoplasms
    Gene Expression Profiling
    Lung Neoplasms
    Transcriptome
    Access Rights
    Free to All
  • Flura-Seq Identifies In Situ Transcriptomes of Micrometastases

    Authors
    Basnet, Harihar
    Macalinao, Danilo Reynaldo Galindez
    Massagué, Joan
    Description

    Summary from the GEO: "Understanding the biology of rare cell populations in the context of their microenvironment requires an accurate analysis of the transcriptomes of these cells as expressed in situ. We developed fluorouracil-tagged RNA sequencing (Flura-seq) to characterize the transcriptomes of small cell subpopulations from a whole organ in model systems. The method utilizes cytosine deaminase...

    Subject
    Brain Neoplasms
    Breast Neoplasms
    Gene Expression Profiling
    Lung Neoplasms
    Transcriptome
    Transforming Growth Factor beta
    Access Rights
    Free to All
  • Glioma (MSKCC, Clin Cancer Res 2019): Targeted sequencing on MSK-IMPACT and FMI Panels of 1004 samples (837 with matched normals) from 923 glioma patients.

    Description

    This dataset contains summary data visualizations and clinical data from 1,004 samples of glioma tumors from 924 patients. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, patient demographics, disease status, and sample details....

    Subject
    Brain Neoplasms
    DNA Mutational Analysis
    Access Rights
    Free to All
  • NCI-60 Cell Lines (NCI, Cancer Res 2012): Whole-exome sequencing of 67 samples by NCI-60 cell line project

    Description

    This dataset contains summary data visualizations and clinical data from 67 samples from 67 patients as part an NCI-60 cell line project to compile NCI-60 cell line high-throughput and high-content data into CellMiner, a genomic and pharmacologic database created by the National Cancer Center Institute. The clinical data includes deidentified patient and sample IDs, mutation counts, detailed cancer...

    Subject
    Adenocarcinoma
    Brain Neoplasms
    Breast Neoplasms
    Carcinoma, Renal Cell
    Colorectal Neoplasms
    DNA Mutational Analysis
    Leukemia, Myeloid
    Lung Neoplasms
    Melanoma
    Ovarian Neoplasms
    Prostatic Neoplasms
    Access Rights
    Free to All
  • Brain Lower Grade Glioma (TCGA, Firehose Legacy)

    Description

    TCGA Brain Lower Grade Glioma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 530 carcinomas from 516 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information...

    Subject
    Astrocytoma
    Brain Neoplasms
    DNA Mutational Analysis
    Glioma
    Oligodendroglioma
    Access Rights
    Free to All
  • Characterization of tumor initiating cells from human glioblastoma multiforms by scRNA seq

    Authors
    Wang, Rong
    Sharma, Roshan
    Laughney, Ashley Marie
    Masilionis, Ignas
    2 more author(s)...
    Description

    Summary from the GEO: Radial Glia (RG) cells are the first neural stem cells to appear during embryonic development. Human embryonic RG cells demonstrates a specific set of gene expression compared to other type of progenitor cells. The goal of this study is to characterize the potential origine of tumor initiating cells of human glioblastoma multiforms by single cell RNASeq analyses of freshly sorted...

    Subject
    Brain Neoplasms
    Ependymoglial Cells
    Glioblastoma
    Access Rights
    Free to All
  • Glioma International Case Control Study (GICC)

    Authors
    Bondy, Melissa L.
    Description

    Study Description from dbGaP: "The main goals of the GICC Study were: 1) to identify novel genetic risk variants for glioma, as well as validate variants implicated by previous genome-wide association studies of glioma; and 2) to explore biologically relevant gene-gene and gene-environment interactions in glioma susceptibility." Study Inclusion Criteria: "Diagnosis of histologically confirmed, supratentorial,...

    Subject
    Astrocytoma
    Brain Neoplasms
    Glioblastoma
    Glioma
    Oligodendroglioma
    Access Rights
    Application Required
  • RNA-seq on parental and acquired resistant cells (AqR)

    Description

    Summary from the GEO: "Parental and AqR cells were obtained at diferent time-points (Day1 and Day 18). Total RNA was extracted and submitted for RNA-seq. Differential expression was observed between parental and AqR cells. AqR cells were derived from parental cells by adding inhibitor (CAY10566) every 3 days until cells became resistant (at about 3 weeks)." Overall Design from the GEO: "2 parental...

    Subject
    Brain Neoplasms
    Glioblastoma
    Stearoyl-CoA Desaturase
    Access Rights
    Free to All