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Results Found: 24
  • Transcriptional and epigenetic regulation of adaptive NK cell responses [ChIP-Seq]

    Alternate Title(s)
    Regulation of natural killer cells during MCMV infection
    Authors
    Lau, Colleen M.
    Sun, Joseph C.
    Description

    Natural killer (NK) cells are innate lymphocytes that possess features of adaptive immunity such as clonal expansion and generation of long-lived memory. Interleukin (IL)-12 signaling through its downstream transcription factor STAT4 is required for the generation of memory NK cells following expansion, while type I interferon through STAT1 is important for NK cell expansion. Here, we identify gene...

    Subject
    Interferon Regulatory Factors
    Interleukin-12
    Killer Cells, Natural
    Transcription Factors
    Access Rights
    Free to All
  • Transcriptional regulation of adaptive NK and CD8 T cell responses [RNA-Seq]

    Alternate Title(s)
    Regulation of natural killer cells during MCMV infection
    Authors
    Lau, Colleen M.
    Sun, Joseph C.
    Description

    Natural killer (NK) cells are innate lymphocytes that possess features of adaptive immunity such as clonal expansion and generation of long-lived memory. Here we look at transcriptional profiles of NK cells throughout several time points during MCMV infection, ex-vivo cytokine stimulation, and/or deficiency of key transcription factors such as STAT4, STAT1, and Runx1. In addition, we profile parallel...

    Subject
    Killer Cells, Natural
    Mouse Cytomegalovirus
    T-Lymphocytes, Cytotoxic
    Transcription Factors
    Viral Infections
    Access Rights
    Free to All
  • Discovery of a Drug Candidate for GLIS3-Associated Diabetes

    Authors
    Amin, Sadaf
    Cook, Brandoch
    Zhou, Ting
    Ghazizadeh, Zaniar
    13 more author(s)...
    Description

    Comparison of WT and GLIS3-/- cells at various stages of human pancreatic differentiation. From Gene Expression Omnibus authors' summary: "Through development and use of a minimal component protocol for derivation of late stage pancreatic progenitors and beta-like cells, we compared WT and GLIS3-/- pancreatic cells at different stages and discovered that GLIS3-/- cells show an ectopic activation...

    Subject
    Cell Differentiation/genetics
    Diabetes Mellitus
    Human Embryonic Stem Cells
    Hypoglycemic Agents
    Insulin-Secreting Cells
    Transcription Factors
    Access Rights
    Free to All
  • Nodal signaling maintains H3K18ac landscape to promote mesendodermal differentiation through TRIM33

    Authors
    Luo, Maoguo
    Bai, Jianbo
    Liu, Bofeng
    Yan, Peiqiang
    13 more author(s)...
    Description

    ATAC-seq, RNA-seq, and ChIP-seq datasets supporting the article "H3K18ac Primes Mesendodermal Differentiation upon Nodal Signaling". From GEO authors' summary: "The epigenome of a cell is established and maintained by chromatin modifiers and remodelers, which are recruited to the chromatin by specific transcription factors. In this report, we show that nodal cross-talks with the epigenome through...

    Subject
    Gene Expression Profiling
    Transcription Factors
    Access Rights
    Free to All
  • RNA-sequencing of Rreb1+/+ and Rreb1-/- embryonic day 7.5 mouse embryos

    Authors
    Morgani, Sophie M. C.
    Hadjantonakis, Anna-Katerina
    Description

    Summary from the GEO: "RNA-sequencing of Rreb1+/+ and Rreb1-/- embryonic day 7.5 mouse embryos" Overall design from the GEO: "RNA-sequencing of Rreb1+/+ and Rreb1-/- embryonic day 7.5 mouse embryos. Mouse embryos were collected at embryonic day 7.5 from intercrosses between Rreb1+/- mice. Samples of the parietal endoderm were taken during dissection for genotyping. Embryos were immediately frozen...

    Subject
    DNA-Binding Proteins
    Transcription Factors
    Access Rights
    Free to All
  • MeRIP-seq mapping of m6A in the IFN-β induced transcriptome in Huh7 cells

    Authors
    McFadden, Michael J.
    McIntyre, Alexa B R
    Gokhale, Nandan S.
    Mason, Christopher E
    1 more author(s)...
    Description

    Summary from the GEO: "The RNA modification N6-methyladenosine (m6A) regulates gene expression through various transcript-specific effects. The goal of this experiment was to identify m6A-modified transcripts during the type I interferon response, with interest in determining which interferon-stimulated genes are modified by m6A. We found that a high percentage of ISGs are m6A-modified, and in follow-up...

    Subject
    Gene Expression
    Interferon Type I
    Interferons
    Transcription Factors
    Access Rights
    Free to All
  • SATB2 induces transcriptional programs in melanoma that lead to metastatic behavior [ChIP-Seq]

    Authors
    van Rooijen, Ellen
    Yang, Song
    Zhou, Yi
    Trompouki, Eirini
    1 more author(s)...
    Description

    Summary from the GEO: "We report the distribution of human SATB2 in a primary zebrafish melanoma that overexpresses human SATB2, and H3K27Ac histone marks in zebrafish melanomas overexpressing either EGFP (control) or human SATB2." Overall design from the GEO: "Examining SATB2 bound regions, and H3K27Ac-bound (super) enhancers in zebrafish melanomas." Abstract summary: "Recent genomic and scRNA-seq...

    Subject
    Histones
    Matrix Attachment Region Binding Proteins
    Melanoma
    Transcription Factors
    Access Rights
    Free to All
  • SATB2 induces transcriptional programs in melanoma that lead to metastatic behavior [RNA-Seq]

    Authors
    van Rooijen, Ellen
    Yang, Song
    Zhou, Yi
    Zon, Leonard I.
    Description

    Summary from the GEO: "We report gene expression data for zebrafish melanomas overexpressing human SATB2 and EGFP." Overall design from the GEO: "RNA-seq was performed on three biological replicates of primary zebrafish melanoma tumors that were excized from MCR:EGFP (control) and MCR:SATB2 overexpressing Tg(BRAF V600E);p53-/-; mitf-/- zebrafish." Abstract summary: "Recent genomic and scRNA-seq...

    Subject
    Matrix Attachment Region Binding Proteins
    Melanoma
    Transcription Factors
    Access Rights
    Free to All
  • Data from: Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1

    Authors
    Jin, Shuiling
    Su, Hairui
    Tran, Ngoc-Tung
    Song, Jing
    6 more author(s)...
    Description

    Summary from Dryad: "Abstract: More than 60% of myeloid dysplasia syndrome (MDS) contains mutations in genes encoding for splicing factors such as SF3B1, U2AF, SRSF2 and ZRSR2. Mutations in SF3B1 are associated with 80% cases of refractory anemia with ring sideroblast (RARS), a subtype of MDS. SF3B1K700E is the most frequently mutated site among mutations on SF3B1. Yet the molecular mechanisms on...

    Subject
    Alternative splicing
    K562 Cells
    Myelodysplastic Syndromes
    Transcription Factors
    Access Rights
    Free to All
  • ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer

    Authors
    Li, Dan
    Chen, Yu
    Chi, Ping
    Zhan, Yu
    16 more author(s)...
    Description

    Summary from Dryad: "Abstract: The mechanisms underlying ETS-driven prostate cancer initiation and progression remain poorly understood due to a lack of model systems that recapitulate this phenotype. We generated a genetically engineered mouse with prostate-specific expression of the ETS factor, ETV4, at lower and higher protein dosages through mutation of its degron. Lower-level expression of...

    Subject
    Prostatic Neoplasms
    Sequence Analysis, RNA
    Transcription Factors
    Tumor Suppressor Protein p53
    Access Rights
    Free to All